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Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection
(2015)
The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using ...
An evaluation of indirubin analogues as phosphorylase kinase inhibitors
(2015)
Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2 diabetes and more recently, cancer (Camus et al., 2012 [6]). However, with few reported structural ...
European surveillance network for influenza in pigs: Surveillance programs, diagnostic tools and swine influenza virus subtypes identified in 14 European countries from 2010 to 2013
(2014)
Swine influenza causes concern for global veterinary and public health officials. In continuing two previous networks that initiated the surveillance of swine influenza viruses (SIVs) circulating in European pigs between ...
Glycogen phosphorylase as a target for type 2 diabetes: Synthetic, biochemical, structural and computational evaluation of novel N-acyl-N´-(β-D-glucopyranosyl) urea inhibitors
(2015)
Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ...
The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis
(2014)
Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the ...
Bayley-III scales at 12 months of corrected age in preterm infants: Patterns of developmental performance and correlations to environmental and biological influences
(2015)
Background and aims: Premature infants are at high risk for neurodevelopmental impairment (NDI) even in the absence of known brain complications of prematurity. Evaluation of the effectiveness of therapeutic interventions ...
Cognition, physical activity, sociodemographic characteristics and “emotional stability”: Their connection with smoking cessation
(2015)
OBJECTIVE To examine the relationship of the cognition of smokers who wish to quit smoking, and seek aid from a psychologist, with their sociodemographic characteristics, and to investigate the role of physical activity ...
Symptomatic cervical perineural (Tarlov) cyst: A case report
(2015)
Background: Perineural (Tarlov) cysts are benign, usually asymptomatic, cerebrospinal fluid filled cysts of the spine, most often found in the sacral region. Description of case:We report a Tarlov cyst, located in the ...
Occupation as a risk factor for carpal tunnel syndrome
(2015)
Carpal tunnel syndrome (CTS) is a neurological disease caused by the compression of the median nerve which runs from the forearm into the palm of the hand. It is attributed to both genetic and environmental factors. ...
Telemetric detection of chronic obstructive pulmonary disease and investigation of quality of life for people working in shipbuilding industry
(2014)
Introduction: Chronic Obstructive Pulmonary Disease (COPD) has a significant impact on quality of life-related health. Aim: It was the detection of Chronic Obstructive Pulmonary Disease by using telemetric methods and the ...