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Genetic assessment of familial and early-onset Parkinson's disease in a Greek population
(2014)
Background and purpose Although the first mutation associated with Parkinson's disease (PD) was identified several years ago in the alpha-synuclein (SNCA) gene in families of Greek and Italian ancestry, a more systematic ...
Restless legs syndrome does not affect 3-year mortality in hemodialysis patients
(2015)
Objective: Uremic restless legs syndrome (RLS) has been related to an enhanced mortality of hemodialysis (HD) patients. In the general population studies of this association have yielded inconsistent results. The aim of ...
The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides
(2013)
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. ...
Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage
(2011)
Objectives Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of intracerebral hemorrhage (ICH) have provided conflicting results. Moreover, ...
Uremic Versus Idiopathic Restless Legs Syndrome: Impact on Aspects Related to Quality of Life
(2012)
Restless legs syndrome (RLS) affects both the general population and patients with chronic renal failure. Even though it has been suggested that all forms of RLS share a common pathophysi-ology, not much evidence exists ...
Genetic factors influencing outcome from neurotrauma
(2012)
Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ...
Periodic Limb Movements in Sleep Contribute to Further Cardiac Structure Abnormalities in Hemodialysis Patients with Restless Legs Syndrome
(2013)
Study Objectives: In hemodialysis (HD) patients, restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) constitute common sleep disorders. Recent findings indicate a role for PLMS as a risk factor in the ...
Non-Pharmacological Management of Periodic Limb Movements During Hemodialysis Session in Patients With Uremic Restless Legs Syndrome
(2010)
Restless legs syndrome (RLS) is very common in hemodialysis patients. RLS induces motor excitability and discomfort during rest periods, and those symptoms have also been observed during hemodialysis sessions. The aim of ...