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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

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Author
Dardiotis, E.; Jagiella, J.; Xiromerisiou, G.; Dardioti, M.; Vogiatzi, C.; Urbanik, A.; Paterakis, K.; Komnos, A.; Fountas, K. N.; Slowik, A.; Hadjigeorgiou, G. M.
Date
2011
DOI
10.1097/FPC.0b013e328343ab15
Keyword
angiotensin-converting enzyme
genes
genetic association studies
intracerebral hemorrhage
polymorphism
tag single nucleotide
polymorphisms
INSERTION-DELETION POLYMORPHISM
CEREBROVASCULAR-DISEASE
ALZHEIMERS-DISEASE
GENE
RISK
STROKE
METAANALYSIS
ASSOCIATION
SYSTEM
Biotechnology & Applied Microbiology
Genetics & Heredity
Pharmacology
& Pharmacy
Metadata display
Abstract
Objectives Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of intracerebral hemorrhage (ICH) have provided conflicting results. Moreover, it is possible that the ACE I/D polymorphism may not represent the functional variant of the gene. The objective of this study was to clarify the influence of the ACE gene region on the risk of ICH by genotyping tag polymorphisms along ACE gene in two independent ethnically different cohorts. Methods We included 250 Greek and 169 Polish unrelated patients with ICH and 250 Greek and 322 Polish normal controls in the study. To cover the majority of the genetic variability across the extended ACE gene region, we identified five tag single nucleotide polymorphisms (rs4343, rs4461142, rs7221780, rs8066276, rs8066114) from the HapMap using a pairwise tagging approach and an r2 greater than or equal to 0.8. Single nucleotide polymorphisms and haplotypes were analyzed for associations with ICH risk, ICH subtype (lobar/nonlobar), and age of disease onset using logistic and Cox regression models. Correction for multiple comparisons was carried out. Results In the Polish cohort, we observed a trend toward an association between the rs4461142 and the age of ICH onset (hazard ratio 0.50, 95% confidence interval 0.27-0.90, P=0.02). A common haplotype (GTCTC) also showed a trend for increased ICH risk in the Polish cohort (odds ratio 0.19, 95% confidence interval 0.04-0.85, P=0.02). These results were not replicated in the Greek cohort. Conclusions Our results did not provide clear evidence for a role of ACE gene in the development of ICH. Pharmacogenetics and Genomics 21:136-141 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
URI
http://hdl.handle.net/11615/26929
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19672]
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