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A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
(2011)
High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...
4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects
(2006)
In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists with moderate potency against CDK2-cyclin E. A preliminary SAR ...
Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients
(2003)
STUDY OBJECTIVES: Obstructive sleep apnea syndrome (OSA) is accompanied by oxygen desaturation and arousal from sleep. Free oxygen radicals are highly reactive molecules which could be produced by the OSA phenomenon of ...
Determinants of healthcare utilization in Greece: Implications for decision-making
(2007)
Objective: To explore factors influencing the utilization of primary and secondary healthcare in Greece. Methods: A national, geographically stratified sample was randomly selected. From November 2001 to March 2002, 5000 ...
Discrimination of exudative pleural effusions based on multiple biological parameters
(2007)
Pleural effusion is a common complication of various diseases. Conventional methods are not always capable of establishing the cause of pleural effusion, so alternative tests are needed. The aim of this study was to explore ...
The influence of β-blockade on the hemodynamic effects of levosimendan in elderly (≥=70 years) patients with acutely decompensated systolic heart failure
(2009)
The purpose of this study was to evaluate the influence of chronic β-blockade on the hemodynamic parameters in elderly (≥70 years) patients with acutely decompensated systolic heart failure treated with levosimendan. ...
Baseline levels of CD8+ T cells against survivin and survivin-2B in the blood of lung cancer patients and cancer-free individuals
(2008)
Survivin and its variant survivin-2B have been considered as potential candidates for cancer immunotherapy. The magnitude however of spontaneously occurring CD8+ T cells circulating precursor CTLs (pCTL), has never been ...
Validation of a Greek version of PSS-14; A global measure of perceived stress
(2012)
Aim: To evaluate validity of the Greek version of a global measure of perceived stress PSS-14 (Perceived Stress Scale - 14 item). Materials and Methods: The original PSS.14 (theoretical range 0.56) was translated into Greek ...
Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human
(2008)
This paper highlights our experience of the transfer of hydrodynamic gene therapy (HGT) from the large animal, the pig, into clinical practice. The modification of balloon catheters and the development of a minimally ...
Applicability of the planned behavior theory to attitudes of students in early childhood education toward teaching culturally diverse classes: The role of self-identity
(2007)
The present study was designed to examine the predictive utility of planned behavior theory to the multicultural education domain. One hundred and forty-eight students in early childhood studies (146 women, 2 men; M age = ...