Αναζήτηση
Αποτελέσματα 1-10 από 11
Large-scale replication and heterogeneity in Parkinson disease genetic loci
(2012)
Objective: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which ...
THAP1 mutations and dystonia phenotypes: Genotype phenotype correlations
(2012)
THAP1 mutations have been shown to be the cause of DYT6. A number of different mutation types and locations in the THAP1 gene have been associated with a range of severity and dystonia phenotypes, but, as yet, it has been ...
Network Analysis of Randomized Controlled Trials in Multiple Sclerosis
(2012)
Background: The optimal treatment of multiple sclerosis (MS) is not yet well-defined. Objective: To estimate the relative effectiveness of treatments in MS, we performed a network of multiple-treatments meta-analysis of ...
Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease
(2012)
Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphateindependent receptor for glucocerebrosidase ...
Perimetric and retinal nerve fiber layer findings in patients with Parkinson's disease
(2012)
Background: Visual dysfunction is common in Parkinson's disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings ...
Role of endoscopic third ventriculostomy in treatment of selected patients with normal pressure hydrocephalus
(2012)
Objective: The purpose of our study was to evaluate the results of endoscopic third ventriculostomy (ETV) in the management of patients with idiopathic normal pressure hydrocephalus (INPH). Methods: Our prospective study ...
Investigation of Unmedicated Early Onset Restless Legs Syndrome by Voxel-Based Morphometry, T2 Relaxometry, and Functional MR Imaging during the Night-Time Hours
(2012)
BACKGROUND AND PURPOSE: The pathophysiology of eRLS has not yet been elucidated. The purpose of the study was to assess, in patients with eRLS, the volume, iron content, and activation of the brain during night-time episodes ...
Cognitive impairment in heart failure
(2012)
Cognitive impairment (CI) is increasingly recognized as a common adverse consequence of heart failure (HF). Although the exact mechanisms remain unclear, microembolism, chronic or intermittent cerebral hypoperfusion, and/or ...
Uremic Versus Idiopathic Restless Legs Syndrome: Impact on Aspects Related to Quality of Life
(2012)
Restless legs syndrome (RLS) affects both the general population and patients with chronic renal failure. Even though it has been suggested that all forms of RLS share a common pathophysi-ology, not much evidence exists ...
Genetic factors influencing outcome from neurotrauma
(2012)
Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ...