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P38 MAPK signaling in pemphigus: Implications for skin autoimmunity

Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Spyrou, V.; Sakkas, L. I.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)

p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ...

Salmonella enteritidis infection complicated by acute myocarditis: A case report and review of the literature

Rigopoulou, E. I.; Papamichalis, P.; Argyraki, K.; Papamichalis, M.; Loukopoulos, A.; Dalekos, G. N. (2011)

Salmonella spp. is the cause of commonly encountered infections, with seasonal pattern of occurrence and worldwide distribution. Some of the clinical manifestations such as gastroenteritis and bacteremia are common, whereas ...

Autoantibodies in autoimmune pancreatitis

Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)

Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ...

Fetomaternal alloimmunity as a cause of liver disease

Smyk, D.; Grammatikopoulos, T.; Daponte, A.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)

Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ...

Hair dyes as a risk for autoimmunity: From systemic lupus erythematosus to primary biliary cirrhosis

Smyk, D.; Rigopoulou, E. I.; Bizzaro, N.; Bogdanos, D. P. (2013)

Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized ...

Towards systemic sclerosis and away from primary biliary cirrhosis: The case of PTPN22

Smyk, D. S.; Mytilinaiou, M. G.; Milkiewicz, P.; Rigopoulou, E. I.; Invernizzi, P.; Bogdanos, D. P. (2012)

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium size intrahepatic bile ducts. PBC patients often have concomitant autoimmune ...

Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its lactobacillus mimic

Bogdanos, D. P.; Baum, H.; Okamoto, M.; Montalto, P.; Sharma, U. C.; Rigopoulou, E. I.; Vlachogiannakos, J.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2005)

The serological hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs). Anti-PDC-E2 antibodies cross-react specifically with ...

Mycophenolate for the treatment of autoimmune hepatitis: Prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naïve patients

Zachou, K.; Gatselis, N.; Papadamou, G.; Rigopoulou, E. I.; Dalekos, G. N. (2011)

Background & Aims: Standard therapy for autoimmune hepatitis (AIH) is corticosteroids with or without azathioprine. However, 20% of patients do not respond or are intolerant to conventional treatment. Therefore, we evaluated ...

Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus-infected patients is associated with the possession of HLA B51

Bogdanos, D. P.; Lenzi, M.; Okamoto, M.; Rigopoulou, E. I.; Muratori, P.; Ma, Y.; Muratori, L.; Tsantoulas, D.; Mieli-Vergani, G.; Bianchi, F. B.; Vergani, D. (2004)

Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected ...