• English
    • Ελληνικά
    • Deutsch
    • français
    • italiano
    • español
  • English 
    • English
    • Ελληνικά
    • Deutsch
    • français
    • italiano
    • español
  • Login
View Item 
  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
All of DSpace
  • Communities & Collections
  • By Issue Date
  • Authors
  • Titles
  • Subjects

Autoantibodies in autoimmune pancreatitis

Thumbnail
Author
Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P.
Date
2012
DOI
10.1155/2012/940831
Keyword
amylase 2alpha antibody
antinuclear antibody
autoantibody
carbonic anhydrase II antibody
carbonic anhydrase IV antibody
corticosteroid
heat shock protein 10 antibody
lactoferrin antibody
pancreatic secretory trypsin inhibitor antibody
plasminogen binding protein antibody
trypsinogen antibody
unclassified drug
antibody production
antibody response
antibody specificity
antibody titer
autoimmune pancreatitis
chronic pancreatitis
diagnostic accuracy
disease association
human
idiopathic chronic pancreatitis
immunopathology
immunoreactivity
insulin dependent diabetes mellitus
nonhuman
pathogenesis
priority journal
review
risk factor
Metadata display
Abstract
Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled out through radiological, serological, and histological investigations. The targets of ANA in patients with autoimmune pancreatitis do not appear to be similar to those found in other rheumatological diseases, as dsDNA, SS-A, and SS-B are not frequently recognized by AIP-related ANA. Other disease-specific autoantibodies, such as, antimitochondrial, antineutrophil cytoplasmic antibodies or diabetes-specific autoantibodies are virtually absent. Further studies have focused on the identification of pancreas-specific autoantigens and reported significant reactivity to lactoferrin, carbonic anhydrase, pancreas secretory trypsin inhibitor, amylase-alpha, heat-shock protein, and plasminogen-binding protein. This paper discusses the findings of these investigations and their relevance to the diagnosis, management, and pathogenesis of autoimmune pancreatitis. © 2012 Daniel S. Smyk et al.
URI
http://hdl.handle.net/11615/33118
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9728]

Related items

Showing items related by title, author, creator and subject.

  • Thumbnail

    Ileal InflammationMay Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn's Disease 

    Pavlidis, P.; Romanidou, O.; Roggenbuck, D.; Mytilinaiou, M. G.; Al-Sulttan, F.; Liaskos, C.; Smyk, D. S.; Koutsoumpas, A. L.; Rigopoulou, E. I.; Conrad, K.; Forbes, A.; Bogdanos, D. P. (2012)
    Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 ...
  • Thumbnail

    Crohn's disease-specific pancreatic autoantibodies are specifically present in ruminants with paratuberculosis: Implications for the pathogenesis of the human disease 

    Liaskos, C.; Spyrou, V.; Roggenbuck, D.; Athanasiou, L. V.; Orfanidou, T.; Mavropoulos, A.; Reinhold, D.; Rigopoulou, E. I.; Amiridis, G. S.; Billinis, C.; Bogdanos, D. P. (2013)
    Mycobacterium avium subspecies paratuberculosis (MAP) induces paratuberculosis (ptb) in ruminants and has clinical and histological features resebling Crohn's disease (CD). Pancreatic autoantibodies (PAB) targeting ...
  • Thumbnail

    Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies 

    Bogdanos, D. P.; Rigopoulou, E. I.; Smyk, D. S.; Roggenbuck, D.; Reinhold, D.; Forbes, A.; Laass, M. W.; Conrad, K. (2011)
    Pancreatic autoantibodies (PAB) giving characteristic staining patterns of the exocrine pancreas by indirect immunoflourescence appear to be specific markers of Crohn's disease (CrD), being present in approximarely 30% of ...
Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
Ψηφιακή Ελλάδα
ΕΣΠΑ 2007-2013
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister (MyDspace)
Help Contact
DepositionAboutHelpContact Us
Choose LanguageAll of DSpace
EnglishΕλληνικά
Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
Ψηφιακή Ελλάδα
ΕΣΠΑ 2007-2013