Listar por autor "Poulou, A."
Mostrando ítems 1-20 de 21
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Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay
Pournaras, S.; Vrioni, G.; Neou, E.; Dendrinos, J.; Dimitroulia, E.; Poulou, A.; Tsakris, A. (2011)Antibiotic combinations including tigecycline have not been studied against Klebsiella pneumoniae carbapenemase (KPC)-producing pathogens. Tigecycline alone and combined with colistin and meropenem was tested against eight ... -
Characteristics of Meropenem Heteroresistance in Klebsiella pneumoniae Carbapenemase (KPC)-Producing Clinical Isolates of K-pneumoniae
Pournaras, S.; Kristo, I.; Vrioni, G.; Ikonomidis, A.; Poulou, A.; Petropoulou, D.; Tsakris, A. (2010)Meropenem heteroresistance was investigated in six apparently meropenem-susceptible, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) clinical isolates, compared with that in carbapenemase-negative, ... -
Characterization of In3Mor, a new integron carrying VIM-1 metallo-beta-lactamase and sat1 gene, from Morganella morganii
Tsakris, A.; Ikonomidis, A.; Spanakis, N.; Poulou, A.; Pournaras, S. (2007)Objectives: A carbapenem-resistant Morganella morganii clinical isolate that was phenotypically metallo-beta-lactamase (MBL)-positive was recovered from a Greek patient. The aim of the study was to analyse the structure ... -
Clusters of imipenem-resistant Acinetobacter baumannii clones producing different carbapenemases in an intensive care unit
Tsakris, A.; Ikonomidis, A.; Poulou, A.; Spanakis, N.; Vrizas, D.; Diomidous, M.; Pournaras, S.; Markou, F. (2008)During a 2-year period (April 2005-March 2007), 31 intensive care unit (ICU) patients in a Greek hospital were infected or colonised with imipenem-resistant isolates of Acinetobacter baumannii. Twelve patients died, with ... -
A Combined Disk Test for Direct Differentiation of Carbapenemase-Producing Enterobacteriaceae in Surveillance Rectal Swabs
Pournaras, S.; Zarkotou, O.; Poulou, A.; Kristo, I.; Vrioni, G.; Themeli-Digalaki, K.; Tsakris, A. (2013)Carbapenemase-producing Enterobacteriaceae (CPE) are rapidly spreading worldwide. Early detection of fecal CPE carriers is essential for effective infection control. Here, we evaluated the performance of a meropenem combined ... -
Comparative Evaluation of Combined-Disk Tests Using Different Boronic Acid Compounds for Detection of Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Clinical Isolates
Tsakris, A.; Themeli-Digalaki, K.; Poulou, A.; Vrioni, G.; Voulgari, E.; Koumaki, V.; Agodi, A.; Pournaras, S.; Sofianou, D. (2011)The accurate phenotypic detection of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae is an increasing necessity worldwide. We evaluated the performance of boronic acid combined-disk tests using as ... -
Detection of the new metallo-beta-lactamase VIM-19 along with KPC-2, CMY-2 and CTX-M-15 in Klebsiella pneumoniae
Pournaras, S.; Poulou, A.; Voulgari, E.; Vrioni, G.; Kristo, I.; Tsakris, A. (2010)To report the identification of the metallo-beta-lactamase (MBL) variant VIM-19 in a Klebsiella pneumoniae clinical strain co-producing KPC-2 carbapenemase, CMY-2 cephalosporinase and CTX-M-15 extended-spectrum beta-lactamase. ... -
Dissemination of Clinical Isolates of Klebsiella oxytoca Harboring CMY-31, VIM-1, and a New OXY-2-Type Variant in the Community
Tsakris, A.; Poulou, A.; Markou, F.; Pitiriga, V.; Piperaki, E. T.; Kristo, I.; Pournaras, S. (2011)The aim of the present study was to investigate the epidemiological link of multidrug-resistant Klebsiella oxytoca isolates causing community-onset infections among patients attending our outpatient department and to ... -
Emergence of carbapenem-resistant enterobacter cloacae carrying VIM-4 metallo-beta-lactamase and SHV-2a extended-spectrum beta-lactamase in a conjugative plasmid
Ikonomidis, A.; Spanakis, N.; Poulou, A.; Pournaras, S.; Markou, F.; Tsakris, A. (2007)Enterobacter cloacae strains are still infrequently resistant to carbapenems. A carbapenem-resistant clinical isolate of E. cloacae producing a plasmid-mediated metallo-beta-lactamase (MBL), VIM-4, was recovered from a ... -
Evaluation of Boronic Acid Disk Tests for Differentiating KPC-Possessing Klebsiella pneumoniae Isolates in the Clinical Laboratory
Tsakris, A.; Kristo, I.; Poulou, A.; Themeli-Digalaki, K.; Ikonomidis, A.; Petropoulou, D.; Pournaras, S.; Sofianou, D. (2009)The worldwide increase in the occurrence and dissemination of KPC beta-lactamases among gram-negative pathogens makes critical the early detection of these enzymes. Boronic acid disk tests using different antibiotic ... -
First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests
Tsakris, A.; Kristo, I.; Poulou, A.; Markou, F.; Ikonomidis, A.; Pournaras, S. (2008)To investigate the first KPC carbapenemase-producing Klebsiella pneumoniae isolate from a Greek hospital, including phenotypic methods to aid recognition of this resistance type. A carbapenem-resistant clinical isolate of ... -
Growth Retardation, Reduced Invasiveness, and Impaired Colistin-Mediated Cell Death Associated with Colistin Resistance Development in Acinetobacter baumannii
Pournaras, S.; Poulou, A.; Dafopoulou, K.; Chabane, Y. N.; Kristo, I.; Makris, D.; Hardouin, J.; Cosette, P.; Tsakris, A.; De, E. (2014)Two colistin-susceptible/colistin-resistant (Col(s)/Col(r)) pairs of Acinetobacter baumannii strains assigned to international clone 2, which is prevalent worldwide, were sequentially recovered from two patients after ... -
In Vivo Acquisition of a Plasmid-Mediated bla(KPC-2) Gene among Clonal Isolates of Serratia marcescens
Tsakris, A.; Voulgari, E.; Poulou, A.; Kimouli, M.; Pournaras, S.; Ranellou, K.; Kosmopoulou, O.; Petropoulou, D. (2010)Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of ... -
Inhibitor-based methods for the detection of KPC carbapenemase-producing Enterobacteriaceae in clinical practice by using boronic acid compounds
Pournaras, S.; Poulou, A.; Tsakris, A. (2010)Enterobacteriaceae clinical strains that produce the class A carbapenem-hydrolysing enzyme KPC (Klebsiella pneumoniae carbapenemase) are increasingly reported worldwide, and are already endemic in North and South America, ... -
Large Dissemination of VIM-2-Metallo-beta-Lactamase-Producing Pseudomonas aeruginosa Strains Causing Health Care-Associated Community-Onset Infections
Tsakris, A.; Poulou, A.; Kristo, I.; Pittaras, T.; Spanakis, N.; Pournaras, S.; Markou, F. (2009)During a 3-year period (May 2005 to April 2008), a series of 45 outpatients presented with community-onset urinary tract infections due to carbapenem-resistant Pseudomonas aeruginosa isolates. Forty of them had a history ... -
Mutations conferring colistin resistance development in Acinetobacter baumannii clinical isolates
Dafopoulou, K.; Poulou, A.; Makris, D.; Hadjichristodoulou, C.; Tsakris, A.; Pournaras, S. (2013)The colistin resistance mechanisms in Acinetobacter baumannii are largely unknown. In the present study, we investigated the characteristics and the mechanisms of colistin resistance in two genetically indistinguishable ... -
Recurrent healthcare-associated community-onset infections due to Klebsiella pneumoniae producing VIM-1 metallo-beta-lactamase
Poulou, A.; Spanakis, N.; Pournaras, S.; Pitiriga, V.; Ranellou, K.; Markou, F.; Tsakris, A. (2010)To investigate the extrahospital dissemination of carbapenem-resistant Klebsiella pneumoniae isolates and the mechanisms of acquired resistance. Patients who were referred to the outpatient department of Serres General ... -
A simple phenotypic method for the differentiation of metallo-beta-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates
Tsakris, A.; Poulou, A.; Pournaras, S.; Voulgari, E.; Vrioni, G.; Themeli-Digalaki, K.; Petropoulou, D.; Sofianou, D. (2010)The increasing frequency of class A KPC enzymes and class B metallo-beta-lactamases (MBLs) among Enterobacteriaceae as well as their possible co-production makes their early differentiation urgent. A simple phenotypic ... -
Susceptibility patterns to extended-spectrum cephalosporins among Enterobacteriaceae harbouring extended-spectrum beta-lactamases using the updated Clinical and Laboratory Standards Institute interpretive criteria
Kristo, I.; Pitiriga, V.; Poulou, A.; Zarkotou, O.; Kimouli, M.; Pournaras, S.; Tsakris, A. (2013)We examined the effect of applying the updated 2010 Clinical and Laboratory Standards Institute (CLSI) susceptibility breakpoints for extended-spectrum cephalosporins (ESCs) to detect extended-spectrum beta-lactamase ... -
Transmission in the community of clonal Proteus mirabilis carrying VIM-1 metallo-beta-lactamase
Tsakris, A.; Ikonomidis, A.; Poulou, A.; Spanakis, N.; Pournaras, S.; Markou, F. (2007)Objectives: Several infections among patients attending our outpatient clinic were caused by imipenem-resistant Proteus mirabilis that were phenotypically metallo-beta-lactamase (MBL)-positive. The aim of the study was to ...