Πλοήγηση ανά Συγγραφέα "Mylonis, I."
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Association of protamine 1 with HP1 during spermiogenesis is mediated through their temporal interaction with LBR
Mylonis, I.; Voukkalis, N.; Sanidas, I.; Drosou, V.; Nikolakaki, E.; Sassone-Corsi, P.; Giannakouros, T. (2007) -
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1 alpha by MAPK
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2008)Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible genes and an important anti-cancer target. Its regulated subunit, HIF-1 alpha, is controlled by oxygen levels and major signaling ... -
Casein kinase 1 regulates human hypoxia inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010) -
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
CK1 delta affects cancer cell adaptation to hypoxia by controlling HIF-1 alpha/ARNT complex formation
Kourti, M.; Mylonis, I.; Giakoumakis, N. N.; Ikonomou, G.; Landegren, U.; Lygerou, Z.; Simos, G. (2014) -
CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
Kourti, M.; Ikonomou, G.; Giakoumakis, N. N.; Rapsomaniki, M. A.; Landegren, U.; Siniossoglou, S.; Lygerou, Z.; Simos, G.; Mylonis, I. (2015)Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1 alpha, the inducible subunit of HIF-1 is regulated by oxygen ... -
Cobalt inhibits HIF-2-dependent gene expression by blocking HIF-2 alpha/USF2 interaction in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P. G.; Hu, C. J.; Simos, G.; Liakos, P. (2014) -
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P.; Hu, C. J.; Simos, G.; Liakos, P. (2013)Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen. Although HIF-1 is usually considered as the principal mediator of hypoxic adaptation, several tissues and ... -
The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
Mylonis, I.; Lakka, A.; Tsakalof, A.; Simos, G. (2010)Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ... -
ERK-dependent association of HIF-1 alpha with chromatin via a peptide that can inhibit HIF-1 activity when over-expressed in hepatocellular carcinoma cells
Kourti, M.; Giakoumakis, N. N.; Lygerou, Z.; Simos, G.; Mylonis, I. (2014) -
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Mylonis, I.; Sembongi, H.; Befani, C.; Liakos, P.; Siniossoglou, S.; Simos, G. (2012)Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires reprogramming of cellular metabolism that is essential during both physiological and pathological processes. In contrast to the ... -
Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma
Ioannou, M.; Papamichali, R.; Kouvaras, E.; Mylonis, I.; Vageli, D.; Kerenidou, T.; Barbanis, S.; Daponte, A.; Simos, G.; Gourgoulianis, K.; Koukoulis, G. K. (2009)Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlying mechanisms has been ... -
Identification of a phosphorylation-dependent nuclear export signal in human hypoxia inducible factor HIF-1 alpha
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2007) -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides
Ioannou, M.; Sourli, F.; Mylonis, I.; Barbanis, S.; Papamichali, R.; Kouvaras, E.; Zafiriou, E.; Siomou, P.; Klimi, E.; Simos, G.; Roussaki-Schulze, A. V.; Koukoulis, G. (2009)Background Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha ... -
The inflammatory mediator tumor necrosis factor alpha (TNF alpha) has cell type-dependent effects on hypoxia-inducible factor 1 (HIF-1)
Triantafyllou, E. A.; Tsapournioti, S.; Mylonis, I.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2014) -
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer
Lakka, A.; Mylonis, I.; Bonanou, S.; Simos, G.; Tsakalof, A. (2011)Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ... -
Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Vasilaki, A.; Mylonis, I.; Molyvdas, P. A.; Gourgoulianis, K.; Hatziefthimiou, A. (2014)Background: Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on ... -
MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity
Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ... -
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization
Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ...