Browsing by Author "Liakos, P."
Now showing items 1-20 of 29
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Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner
Vlachostergios, P. J.; Hatzidaki, E.; Befani, C. D.; Liakos, P.; Papandreou, C. N. (2013)Development of drug resistance after standard chemotherapy for glioblastoma multiforme (GBM) with temozolomide (TMZ) is associated with poor prognosis of GBM patients and is at least partially mediated by a direct DNA ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells (vol 90, pg 45, 2012)
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2013) -
Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells
Tsapakidis, K.; Vlachostergios, P. J.; Voutsadakis, I. A.; Befani, C. D.; Patrikidou, A.; Hatzidaki, E.; Daliani, D. D.; Moutzouris, G.; Liakos, P.; Papandreou, C. N. (2012)Objectives: Neuropeptides are important signal initiators in advanced prostate cancer, partially acting through activation of nuclear factor kappa B. Central to nuclear factor kappa B regulation is the ubiquitin-proteasome ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Cobalt inhibits HIF-2-dependent gene expression by blocking HIF-2 alpha/USF2 interaction in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P. G.; Hu, C. J.; Simos, G.; Liakos, P. (2014) -
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells
Befani, C.; Mylonis, I.; Gkotinakou, I. M.; Georgoulias, P.; Hu, C. J.; Simos, G.; Liakos, P. (2013)Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular response to low oxygen. Although HIF-1 is usually considered as the principal mediator of hypoxic adaptation, several tissues and ... -
Differential regulation of hypoxia inducible factor 1 alpha (HIF-1 alpha) expression and HeLa cell survival and proliferation by hypoxia, desferrioxamine, cobalt and quercetin: the role of iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2005) -
Effect of CRH on NO bioavailability, ROS production and antioxidant defense systems in endothelial EAhy926 cells
Gougoura, S.; Liakos, P.; Koukoulis, G. N. (2010)Local or 'Immune' Corticotropin-Releasing Hormone (CRH) is secreted in peripheral tissues and plays a direct immunomodulatory role as an endocrine or paracrine mediator of inflammation. The present study was undertaken to ... -
Effect of ET-1, FGF-2, and HGF on intracellular steroidogenesis in prostate cancer cells
Vasileiou, C.; Hatzidaki, E.; Karkabounas, A.; Maragkouli, E.; Vaiou, M.; Dimas, K.; Liakos, P.; Lekka, M.; Papandreou, C. (2013) -
Elevation of fetal hemoglobin (HbF) by novel alkylating agents in human erythroid cells; Synergistic effects with established HbF-inducing agents
Chiotoglou, I.; Samara, M.; Likousi, S.; Samara, S.; Iakovidou, Z.; Mioglou, E.; Mourelatos, D.; Papadakis, M.; Liakos, P.; Kollia, P. (2006) -
Emergence of Enterococcus faecalis susceptible to quinupristin/dalfopristin in Greece
Petinaki, E.; Kontos, F.; Maniatis, A. N.; Spiliopoulou, I.; Liakos, P. (2006) -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
FETAL HEMOGLOBIN MODULATION BY NOVEL ALKYLATING AGENTS IN HUMAN ERYTHROID CELLS; SYNERGISTIC EFFECTS WITH ESTABLISHED HBF-INDUCING AGENTS
Chiotoglou, I.; Samara, M.; Paterakis, G.; Likousi, S.; Iakovidou, Z.; Mioglou, E.; Mourelatos, D.; Marinou, I.; Liakos, P.; Kollia, P. (2009) -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Mylonis, I.; Sembongi, H.; Befani, C.; Liakos, P.; Siniossoglou, S.; Simos, G. (2012)Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires reprogramming of cellular metabolism that is essential during both physiological and pathological processes. In contrast to the ... -
Induction of fetal hemoglobin (HbF) by novel alkylating agents in human erythroid cells; synergistic effects with established HbF-inducing agents
Chiotoglou, I.; Samara, M.; Likousi, S.; Samara, S.; Chassanidis, C.; Iakovidou, Z.; Mioglou, E.; Mourelatos, D.; Papadakis, M.; Liakos, P.; Kollia, P. (2008) -
Inhibition of the Na-H + exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: A time course of events
Konstantinidis, D.; Koliakos, G.; Vafia, K.; Liakos, P.; Bantekas, C.; Trachana, V.; Kaloyianni, M. (2006)Aims: The present study attempts to shed light on the role and the relative position of the Na +/H + exchanger isoform 1 (NHE1) and the extracellular signal-regulated kinase (ERK) in HEp-2 cell signaling pathways concerning ... -
Latanoprost therapy reduces the levels of TGF beta 1 and gelatinases in the aqueous humour of patients with exfoliative glaucoma
Konstas, A. G. P.; Koliakos, G. G.; Karabatsas, C. H.; Liakos, P.; Schlotzer-Schrehardt, U.; Georgiadis, N.; Ritch, R. (2006)The aim of the present study was to evaluate the effect of latanoprost monotherapy on the aqueous humour concentrations of TGF-beta 1, MMP-2, TIMP-2, MMP-9 and gelatinolytic activity in patients treated for exfoliative ... -
Low Oxygen Tension Enhances Hepatitis C Virus Replication
Vassilaki, N.; Kalliampakou, K. I.; Kotta-Loizou, I.; Befani, C.; Liakos, P.; Simos, G.; Mentis, A. F.; Kalliaropoulos, A.; Doumba, P. P.; Smirlis, D.; Foka, P.; Bauhofer, O.; Poenisch, M.; Windisch, M. P.; Lee, M. E.; Koskinas, J.; Bartenschlager, R.; Mavromara, P. (2013)Low oxygen tension exerts a significant effect on the replication of several DNA and RNA viruses in cultured cells. In vitro propagation of hepatitis C virus (HCV) has thus far been studied under atmospheric oxygen levels ...