Parcourir par auteur "Kouvela, E. C."
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Clindamycin binding to ribosomes revisited: foot printing and computational detection of two binding sites within the peptidyl transferase center
Kostopoulou, O. N.; Papadopoulos, G.; Kouvela, E. C.; Kalpaxis, D. L. (2013)Clindamycin is a semi-synthetic lincosamide, active against most Gram-positive bacteria and some protozoa. It binds to the 50S ribosomal subunit and inhibits early peptide chain elongation. By kinetic analysis it has been ... -
Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol
Kostopoulou, O. N.; Kouvela, E. C.; Magoulas, G. E.; Garnelis, T.; Panagoulias, I.; Rodi, M.; Papadopoulos, G.; Mouzaki, A.; Dinos, G. P.; Papaioannou, D.; Kalpaxis, D. L. (2014)Chloramphenicol (CAM) is a broad-spectrum antibiotic, limited to occasional only use in developed countries because of its potential toxicity. To explore the influence of polyamines on the uptake and activity of CAM into ...