Auflistung nach Autor "Chachami, G."
Anzeige der Dokumente 1-20 von 24
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2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
Braliou, G. G.; Falzacappa, M. V. V.; Chachami, G.; Casanovas, G.; Muckenthaler, M. U.; Simos, G. (2008)Background/Aims: Hepcidin is a liver-produced hormone that regulates systemic iron homeostasis. Hepcidin expression is stimulated upon iron overload or inflammation while iron deficiency, anemia and tissue hypoxia are ... -
An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1 alpha) Polymorphisms and Osteonecrosis
Chachami, G.; Kalousi, A.; Papatheodorou, L.; Lyberopoulou, A.; Nasikas, V.; Tanimoto, K.; Simos, G.; Malizos, K. N.; Georgatsou, E. (2013)Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1 alpha, the major transcription factor triggered by hypoxia, is ... -
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1 alpha by MAPK
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2008)Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible genes and an important anti-cancer target. Its regulated subunit, HIF-1 alpha, is controlled by oxygen levels and major signaling ... -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
Chachami, G.; Paraskeva, E.; Georgatsou, E.; Bonanou, S.; Simos, G. (2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Casein kinase 1 regulates human hypoxia inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010) -
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
Kalousi, A.; Mylonis, I.; Politou, A. S.; Chachami, G.; Paraskeva, E.; Simos, G. (2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
Characterization of the nuclear import pathway for the human hypoxia inducible factor HIF-1alpha
Chachami, G.; Paraskeva, E.; Mingot, J. M.; Gorlich, D.; Simos, G. (2007) -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
Chachami, G.; Simos, G.; Hatziefthimiou, A.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Detection of new molecular partners of hypoxia inducible factor 1 alpha (HIF-1 alpha)
Lyberopoulou, A.; Gadaras, G.; Venieris, E.; Chachami, G.; Simos, G.; Bonanou, S.; Georgatsou, E. (2005) -
Determination and significance of serum hepcidin and liver hepcidin mRNA levels in patients with hepatopathies
Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Eliades, P.; Paraskeva, E.; Zachou, K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2012) -
Down-regulation of hepcidin production in patients with autoimmune liver diseases
Gatselis, N.; Lyberopoulou, A.; Zachou, K.; Chachami, G.; Eliades, P.; Gabeta, S.; Paraskeva, E.; Mamalaki, A.; Koukoulis, G. K.; Simos, G.; Dalekos, G. N. (2014) -
Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect
Darekar, S.; Georgiou, K.; Yurchenko, M.; Yenamandra, S. P.; Chachami, G.; Simos, G.; Klein, G.; Kashuba, E. (2012)Background: Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in ... -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Identification of a phosphorylation-dependent nuclear export signal in human hypoxia inducible factor HIF-1 alpha
Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2007) -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
Inhaled insulin does not trigger lung inflammation and airway remodelling
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2009) -
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2007)Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ... -
Investigation of hepcidin secretion in human hepatocytes
Chachami, G.; Braliou, G.; Paraskeva, E.; Simos, G. (2008) -
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases
Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Kyratzopoulou, E.; Saitis, A.; Gabeta, S.; Eliades, P.; Paraskeva, E.; Zachou, K.; Koukoulis, G. K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2015)Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin ...