Sfoglia per Autore "Burroughs, A. K."
Items 1-13 di 13
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Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection
Bogdanos, D. P.; Baum, H.; Butler, P.; Rigopoulou, E. I.; Davies, E. T.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2003)Background and aims. Recurrent urinary tract infections (rUTI) have been suggested to be involved in the induction of anti-mitochondrial antibodies (AMA), the serological hallmark of primary biliary cirrhosis (PBC), in ... -
Autoantibodies in autoimmune pancreatitis
Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ... -
Autoimmunity and Environment: Am I at risk?
Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ... -
Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis
Mytilinaiou, M. G.; Meyer, W.; Scheper, T.; Rigopoulou, E. I.; Probst, C.; Koutsoumpas, A. L.; Abeles, D.; Burroughs, A. K.; Komorowski, L.; Vergani, D.; Bogdanos, D. P. (2012)Background: The lack of an immunoassay that detects antibodies to promyelocytic leukaemia (PML) protein, the primary biliary cirrhosis (PBC)-specific multiple nuclear dot (MND) antigen, has prompted us to develop a line ... -
Disease-specific cross-reactivity between mimicking peptides of heat shock protein of mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis
Bogdanos, D. P.; Pares, A.; Baum, H.; Caballeria, L.; Rigopoulou, E. I.; Ma, Y.; Burroughs, A. K.; Rodes, J.; Vergani, D. (2004)Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate ... -
Epstein-barr virus as a trigger of autoimmune liver diseases
Rigopoulou, E. I.; Smyk, D. S.; Matthews, C. E.; Billinis, C.; Burroughs, A. K.; Lenzi, M.; Bogdanos, D. P. (2012)The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of ... -
Evidence that an E. coli replication primase peptide, highly homologous to the major sp100 epitope, is a possible trigger of anti-sp100 reactivity in primary biliary cirrhosis
Bogdanos, D. P.; Baum, H.; Butler, P.; Rigopoulou, E. I.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2003) -
Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis
Bogdanos, D. P.; Baum, H.; Grasso, A.; Okamoto, M.; Butler, P.; Ma, Y.; Rigopoulou, E.; Montalto, P.; Davies, E. T.; Burroughs, A. K.; Vergani, D. (2004)Background/Aims: Previous studies on patients with primary biliary cirrhosis (PBC) have shown extensive cross-reactivity between the dominant B- and T-cell epitopes of human pyruvate dehydrogenase complex-E2 (PDC-E2), and ... -
Primary biliary cirrhosis associated with systemic sclerosis: Diagnostic and clinical challenges
Rigamonti, C.; Bogdanos, D. P.; Mytilinaiou, M. G.; Smyk, D. S.; Rigopoulou, E. I.; Burroughs, A. K. (2011)Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The ... -
Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its lactobacillus mimic
Bogdanos, D. P.; Baum, H.; Okamoto, M.; Montalto, P.; Sharma, U. C.; Rigopoulou, E. I.; Vlachogiannakos, J.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2005)The serological hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs). Anti-PDC-E2 antibodies cross-react specifically with ... -
Sex Differences Associated with Primary Biliary Cirrhosis
Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Billinis, C.; Burroughs, A. K.; Muratori, L.; Invernizzi, P.; Bogdanos, D. P. (2012)Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to ... -
Smoking as a risk factor for autoimmune liver disease: What we can learn from primary biliary cirrhosis
Smyk, D. S.; Rigopoulou, E. I.; Muratori, L.; Burroughs, A. K.; Bogdanos, D. P. (2012)Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterised by circulating ... -
Urinary tract infection as a risk factor for autoimmune liver disease: From bench to bedside
Smyk, D. S.; Bogdanos, D. P.; Kriese, S.; Billinis, C.; Burroughs, A. K.; Rigopoulou, E. I. (2012)Autoimmune liver diseases include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis. A variety of environmental and genetic risk factors have been associated with these conditions. ...