Sfoglia per Soggetto "tumor necrosis factor"

Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study

Mettou A., Papaneophytou C., Melagraki G., Maranti A., Liepouri F., Alexiou P., Papakyriakou A., Couladouros E., Eliopoulos E., Afantitis A., Kontopidis G. (2018)

The aim of this study is to improve the aqueous solubility of a group of compounds without interfering with their bioassay as well as to create a relevant prediction model. A series of 55 potential small-molecule inhibitors ...

Assessing the physiological effects of traditional regional diets targeting the prevention of cardiovascular disease: A systematic review of randomized controlled trials implementing mediterranean, New Nordic, Japanese, Atlantic, Persian and Mexican dietary interventions

Klonizakis M., Bugg A., Hunt B., Theodoridis X., Bogdanos D.P., Grammatikopoulou M.G. (2021)

Traditional regional diets are considered as sustainable dietary patterns, while many have been examined with regard to their health benefits. The aim of the present systematic review was to aggerate all evidence on the ...

Association of melatonin administration in pregnant ewes with growth, redox status and immunity of their offspring

Bouroutzika E., Ciliberti M.G., Caroprese M., Theodosiadou E., Papadopoulos S., Makri S., Skaperda Z.-V., Kotsadam G., Michailidis M.-L., Valiakos G., Chadio S., Kouretas D., Valasi I. (2021)

In this study, the effects of melatonin treatment on growth, redox status and immunity in prenatally stressed newborn lambs were evaluated. Thirty-seven newborn lambs were allocated into two groups (melatonin-MEL and ...

BAFF receptor polymorphisms and deficiency in humans

Sevdali E., Block Saldana V., Speletas M., Eibel H. (2021)

The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including ...

Baseline Values and Kinetics of IL-6, Procalcitonin, and TNF- α in Landrace-Large White Swine Anesthetized with Propofol-Based Total Intravenous Anesthesia

Chalkias A., Spyropoulos V., Georgiou G., Laou E., Koutsovasilis A., Pantazopoulos I., Kolonia K., Vrakas S., Papalois A., Demeridou S., Gourgoulianis K., Dontas I., Kaparos G., Baka S., Xanthos T. (2021)

The baseline levels of various inflammatory mediators and their changes during anesthesia in swine are not known. The aim of this animal study was to measure the baseline values and kinetics of interleukin-6, procalcitonin, ...

Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions

Karra A.G., Tziortziou M., Kylindri P., Georgatza D., Gorgogietas V.A., Makiou A., Krokida A., Tsialtas I., Kalousi F.D., Papadopoulos G.E., Papadopoulou K.Κ., Psarra A.-M.G. (2020)

Glucocorticoid (GCs) hormones exert their actions via their cognate steroid receptors the Glucocorticoid Receptors (GR), by genomic or non-genomic mechanisms of actions. GCs regulate many cellular functions among them ...

Breast radiotherapy and early adverse cardiac effects. The role of serum biomarkers and strain echocardiography

Gkantaifi A., Papadopoulos C., Spyropoulou D., Toumpourleka M., Iliadis G., Kardamakis D., Nikolaou M., Tsoukalas N., Kyrgias G., Tolia M. (2019)

Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the ...

Carotid Intima-Media Thickness and Circulation Markers of Inflammation in Patients With Depression

Saleptsis V., Papaliaga M., Spanos K., Kouvelos G., Labropoulos N., Halaris A., Giannoukas A. (2020)

Objective: Growing evidence indicates that depressive disorders (DDs) are an important risk factor for atherosclerosis. The aim of this study was to evaluate the presence of common carotid artery (CCA) intima-media thickness ...

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

Melagraki G., Ntougkos E., Rinotas V., Papaneophytou C., Leonis G., Mavromoustakos T., Kontopidis G., Douni E., Afantitis A., Kollias G. (2017)

We present an in silico drug discovery pipeline developed and applied for the identification and virtual screening of small-molecule Protein-Protein Interaction (PPI) compounds that act as dual inhibitors of TNF and RANKL ...

A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli

Papaneophytou C., Kontopidis G. (2016)

During a discovery project of potential inhibitors for three proteins, TNF-α, RANKL and HO-1, implicated in the pathogenesis of rheumatoid arthritis, significant amounts of purified proteins were required. The application ...

COVID-19 pandemic and cardiovascular disease: where do we stand?

Chatzis D.G., Magounaki K.T., Pantazopoulos I.N., Johnson E.O., Tsioufis K.P. (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) which recently has been characterized as a pandemic by the World Health Organization (WHO) having killed ...

Current status and future prospects of small–molecule protein–protein interaction (PPI) inhibitors of tumor necrosis factor (TNF) and receptor activator of NF-κB ligand (RANKL)

Melagraki G., Leonis G., Ntougkos E., Rinotas V., Papaneophytou C., Mavromoustakos T., Kontopidis G., Douni E., Kollias G., Afantitis A. (2018)

The overexpression of Tumor Necrosis Factor (TNF) is directly related to the development of several autoimmune diseases, such as rheumatoid and psoriatic arthritis, inflammatory bowel disease, Crohn’s disease, refractory ...

Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index

Rinotas V., Papakyriakou A., Violitzi F., Papaneophytou C., Ouzouni M.-D., Alexiou P., Strongilos A., Couladouros E., Kontopidis G., Eliopoulos E., Douni E. (2020)

Receptor activator of nuclear factor-κB ligand (RANKL) constitutes the master mediator of osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has been approved for the treatment of postmenopausal ...

Disease Activity, Functional Ability and Nutritional Status in Patients with Rheumatoid Arthritis: An Observational Study in Greece

Markaki A.G., Gkiouras K., Papakitsos C., Grammatikopoulous M.G., Papatsaraki A., loannou R., Tsagkari A., Papamitsou T., Bogdanos D.P. (2020)

Aim: The aim of the present pilot study was to assess differences in the nutritional status, Mediterranean diet (MD) adherence, and functional ability among patients with rheumatoid arthritis (RA), according to disease ...

Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

Farsalinos K., Niaura R., Le Houezec J., Barbouni A., Tsatsakis A., Kouretas D., Vantarakis A., Poulas K. (2020)

[No abstract available]

Effect of crocus sativus (Saffron) intake on top of standard treatment, on disease outcomes and comorbidities in patients with rheumatic diseases: Synthesis without meta-analysis (SWiM) and level of adherence to the CONSORT statement for randomized controlled trials delivering herbal medicine interventions

Tsiogkas S.G., Grammatikopoulou M.G., Gkiouras K., Zafiriou E., Papadopoulos I., Liaskos C., Dardiotis E., Sakkas L.I., Bogdanos D.P. (2021)

Rheumatic diseases (RDs) are often complicated by chronic symptoms and frequent sideeffects associated with their treatment. Saffron, a spice derived from the Crocus sativus L. flower, is a popular complementary and ...

Efficacy and Safety Profile of Anti-tumor Necrosis Factor-α Versus Anti-integrin Agents for the Treatment of Crohn's Disease: A Network Meta-analysis of Indirect Comparisons

Miligkos M., Papamichael K., Casteele N.V., Mantzaris G.J., Gils A., Levesque B.G., Zintzaras E. (2016)

Purpose To compare the benefits and harms of anti-tumor necrosis factor (TNF)-α and anti-integrin agents as induction and maintenance therapy in adult patients with Crohn's disease. Methods We searched MEDLINE and the ...

Egg Consumption, Cardiovascular Disease and Cardiometabolic Risk Factors: The Interaction with Saturated Fatty Acids. Results from the ATTICA Cohort Study (2002–2012)

Kouvari M., Damigou E., Florentin M., Kosti R.I., Chrysohoou C., Pitsavos C.S., Panagiotakos D.B. (2022)

Purpose: To examine the association of egg intake with 10-year risk of cardiovascular disease (CVD) and other cardiometabolic risk factors in a sample of individuals of Mediterranean origin. Methods: In 2001–2002, n = 1514 ...

Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity?

Flynn M.G., Markofski M.M., Carrillo A.E. (2019)

Age-associated hyper-inflammation or “inflamm-aging” has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address ...

The emerging role of helicobacter pylori-induced metabolic gastrointestinal dysmotility and neurodegeneration

Kountouras J., Boziki M., Polyzos S.A., Katsinelos P., Gavalas E., Zeglinas C., Tzivras D., Romiopoulos I., Giorgakis N., Anastasiadou K., Vardaka E., Kountouras C., Kazakos E., Giartza-Taxidou E., Deretzi G., Dardiotis E., Kotronis G., Doulberis M. (2017)

Helicobacter pylori infection (Hp-I) is a prevalent disorder identified in themajority of the population in many countries around the world and is responsible for substantial gastrointestinal morbidity. Likewise, ...