Πλοήγηση ανά Θέμα "Peptides"

Antioxidant Effects of Sheep Whey Protein on Endothelial Cells

Kerasioti E., Stagos D., Georgatzi V., Bregou E., Priftis A., Kafantaris I., Kouretas D. (2016)

Excessive production of reactive oxygen species (ROS) may cause endothelial dysfunction and consequently vascular disease. In the present study, the possible protective effects of sheep whey protein (SWP) from tert-butyl ...

Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity

Rizos, A. K.; Baritaki, S.; Tsikalas, I.; Doetschman, D. C.; Spandidos, D. A.; Krambovitis, E. (2007)

The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ...

Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study

Liakou C.G., Mastorakos G., Makris K., Fatouros I.G., Avloniti A., Marketos H., Antoniou J.D., Galanos A., Dontas I., Rizos D., Tournis S. (2016)

Studies in postmenopausal women have identified sclerostin as a strong candidate for mediating estrogen effects on the skeleton. The effects of estradiol on sclerostin and Dickkopf-1 in younger women remain unclear. The ...

Confronting multidrug-resistant Acinetobacter baumannii: a review

Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2011)

Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are difficult to treat owing to the extremely limited armamentarium. The present review reports all available treatment options against MDR-AB, including ...

The coordination of unprotonated peptide tertiary structure as a metric of pMHC-TCR functional avidity

Antipas G.S.E., Germenis A.E. (2015)

The coordination difference between the unprotonated tertiary structures of a native (Tax) peptide and a number of its variants - all peptides presented by HLA-A201 and bound to the human A6 T cell receptor-was discovered ...

Cost Effectiveness of Exenatide Once Weekly Versus Insulin Glargine and Liraglutide for the Treatment of Type 2 Diabetes Mellitus in Greece

Tzanetakos C., Bargiota A., Kourlaba G., Gourzoulidis G., Maniadakis N. (2018)

Objective: The objective of this study was to evaluate the long-term cost effectiveness of exenatide once weekly (ExQW) versus insulin glargine (IG) or liraglutide 1.2 mg (Lira1.2mg) for the treatment of adult patients ...

Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation

Beneker C.M., Rovoli M., Kontopidis G., Röring M., Galda S., Braun S., Brummer T., McInnes C. (2019)

Despite the clinical success of BRAF inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through "paradoxical MEK/ERK signaling" where transactivation of one protomer occurs as a result of ...

The effects of calcitonin on acute bone loss after pertrochanteric fractures. A prospective, randomised trial

Karachalios, T.; Lyritis, G. P.; Kaloudis, J.; Roidis, N.; Katsiri, M. (2004)

We investigated the effect of calcitonin in the prevention of acute bone loss after a pertrochanteric fracture and its ability to reduce the incidence of further fractures in the same patient. Fifty women aged between 70 ...

Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation

Sakelliou A., Fatouros I.G., Athanailidis I., Tsoukas D., Chatzinikolaou A., Draganidis D., Jamurtas A.Z., Liacos C., Papassotiriou I., Mandalidis D., Stamatelopoulos K., Dimopoulos M.A., Mitrakou A. (2016)

We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to ...

Evidence of blood and muscle redox status imbalance in experimentally induced renal insufficiency in a rabbit model

Poulianiti K.P., Karioti A., Kaltsatou A., Mitrou G.I., Koutedakis Y., Tepetes K., Christodoulidis G., Giakas G., Maridaki M.D., Stefanidis I., Jamurtas A.Z., Sakkas G.K., Karatzaferi C. (2019)

Chronic kidney disease (CKD) is accompanied by a disturbed redox homeostasis, especially in end-stage patients, which is associated with pathological complications such as anemia, atherosclerosis, and muscle atrophy. ...

HLA class II peptide-binding-region analysis reveals funneling of polymorphism in action

Sarri C.A., Giannoulis T., Moutou K.A., Mamuris Z. (2021)

Background: HLA-class II proteins hold important roles in key physiological processes. The purpose of this study was to compile all class II alleles reported in human population and investigate patterns in pocket variants ...

Large-scale assessment of polyglutamine repeat expansions in Parkinson disease

Wang L., Aasly J.O., Annesi G., Bardien S., Bozi M., Brice A., Carr J., Chung S.J., Clarke C., Crosiers D., Deutschländer A., Eckstein G., Farrer M.J., Goldwurm S., Garraux G., Hadjigeorgiou G.M., Hicks A.A., Hattori N., Klein C., Jeon B., Kim Y.J., Lesage S., Lin J.-J., Lynch T., Lichtner P., Lang A.E., Mok V., Jasinska-Myga B., Mellick G.D., Morrison K.E., Opala G., PihlstrØm L., Pramstaller P.P., Park S.S., Quattrone A., Rogaeva E., Ross O.A., Stefanis L., Stockton J.D., Silburn P.A., Theuns J., Tan E.K., Tomiyama H., Toft M., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Yueh K.-C., Zhao Y., Gasser T., Maraganore D.M., Krüger R., Sharma M. (2015)

Objectives: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). Methods: We invited researchers from the Genetic ...

REPLACE: A strategy for iterative design of cyclin-binding groove inhibitors

Andrews, M. J. I.; Kontopidis, G.; McInnes, C.; Plater, A.; Innes, L.; Cowan, A.; Jewsbury, P.; Fischer, P. M. (2006)

We describe a drug-design strategy termed REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) in which nonpeptidic surrogates for specific determinants of known peptide ligands are ...

Transcriptome Analysis Identifies Immune Markers Related to Visceral Leishmaniasis Establishment in the Experimental Model of BALB/c Mice

Agallou M., Athanasiou E., Kammona O., Tastsoglou S., Hatzigeorgiou A.G., Kiparissides C., Karagouni E. (2019)

Visceral leishmaniasis (VL) caused by Leishmania donovani and L. infantum is a potentially fatal disease. To date there are no registered vaccines for disease prevention despite the fact that several vaccines are in ...

Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin A through structure-guided design

Kontopidis, G.; Andrews, M. J.; McInnes, C.; Plater, A.; Innes, L.; Renachowski, S.; Cowan, A.; Fischer, P. M. (2009)

The cyclin-dependent kinase 2-cyclin A complex is an important regulator of the DNA-synthesis phase of the mammalian cell cycle, which is frequently deregulated in cancer. Rather than blocking the ATP-binding site of the ...