Πλοήγηση ανά Θέμα "Interleukin-10"

Anti-inflammatory effects of a special carbohydrate-whey protein cake after exhaustive cycling in humans

Kerasioti, E.; Stagos, D.; Jamurtas, A.; Kiskini, A.; Koutedakis, Y.; Goutzourelas, N.; Pournaras, S.; Tsatsakis, A. M.; Kouretas, D. (2013)

Intense exercise induces increased levels of pro-inflammatory and anti-inflammatory cytokines. Thus, the purpose of this study was to examine the effects of a special cake (consisting of carbohydrate to whey protein 3.5:1) ...

Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

Mavropoulos A., Zafiriou E., Simopoulou T., Brotis A.G., Liaskos C., Roussaki-Schulze A., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2019)

Objectives: Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory ...

Association of IL-10 gene promoter polymorphisms with food allergy susceptibility and serum IL-10 level in a pediatric Caucasian population

Nedelkopoulou N., Taparkou A., Raftopoulou S., Gidaris D., Xinias I., Mavroudi A., Dhawan A., Farmaki E. (2021)

Background: Interleukin 10 has been shown to play a critical role in the regulation of the immune responses in allergic diseases. Aim: To investigate if genetic polymorphisms in the promoter region of the IL-10 gene are ...

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Madè A., Greco S., Vausort M., Miliotis M., Schordan E., Baksi S., Zhang L., Baryshnikova E., Ranucci M., Cardani R., Fagherazzi G., Ollert M., Tastsoglou S., Vatsellas G., Hatzigeorgiou A., Firat H., Devaux Y., Martelli F. (2022)

Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting ...

Blocking of interleukin-10 receptor - A novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus

Rigopoulou, E. I.; Abbott, W. G. H.; Haigh, P.; Naoumov, N. V. (2005)

Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity and enhanced interleukin-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade ...

Breg Cells Are Numerically Decreased and Functionally Impaired in Patients with Systemic Sclerosis

Mavropoulos A., Simopoulou T., Varna A., Liaskos C., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2016)

Objective Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number ...

Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease

Tsiogkas S.G., Mavropoulos Α., Skyvalidas D.N., Patrikiou E., Ntavari N., Daponte A.I., Grammatikopoulou M.G., Dardiotis E., Roussaki-Schulze A.-V., Sakkas L.I., Zafiriou E., Bogdanos D.P. (2022)

The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin’s in vitro ...

Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Antoniadis, N.; Liakopoulos, V.; Stefanidis, I. (2013)

Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ...

IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells

Mavropoulos A., Varna A., Zafiriou E., Liaskos C., Alexiou I., Roussaki-Schulze A., Vlychou M., Katsiari C., Bogdanos D.P., Sakkas L.I. (2017)

Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10 + Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and ...

IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis

Mavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I. (2017)

We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc ...

Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals

Papoutsopoulou S., Pollock L., Walker C., Tench W., Samad S.S., Bergey F., Lenzi L., Sheibani-Tezerji R., Rosenstiel P., Alam M.T., Martins Dos Santos V.A.P., Müller W., Campbell B.J. (2021)

Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system has been extensively studied, ...

The Indoleamine 2,3-dioxygenase Inhibitor 1-methyl-tryptophan Suppresses Mitochondrial Function, Induces Aerobic Glycolysis and Decreases Interleukin-10 Production in Human Lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I. (2012)

Background: Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. It is known that IDO induces T-cell differentiation to regulatory T-cells (Treg) through tryptophan depletion and/or kynurenine pathway products. ...

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

Ferreiro-Iglesias A., Montes A., Perez-Pampin E., Cañete J.D., Raya E., Magro-Checa C., Vasilopoulos Y., Sarafidou T., Caliz R., Ferrer M.A., Joven B., Carreira P., Balsa A., Pascual-Salcedo D., Blanco F.J., Moreno-Ramos M.J., Fernández-Nebro A., Ordóñez M.C., Alegre-Sancho J.J., Narváez J., Navarro-Sarabia F., Moreira V., Valor L., García-Portales R., Marquez A., Martin J., Gómez-Reino J.J., Gonzalez A. (2016)

Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have ...

The role of B cells in the pathogenesis of systemic sclerosis

Sakkas L.I., Bogdanos D.P. (2016)

Systemic sclerosis (SSc) is characterized by extensive collagen deposition, microvasculopathy and autoantibodies. All three features can be promoted by activation of T cells and B cells. T cells are of Th2 type producing ...

The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis

Kelepouri D., Mavropoulos A., Bogdanos D.P., Sakkas L.I. (2018)

Flavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge. Their role in the manipulation of immunoregulation ...