Πλοήγηση ανά Συγγραφέα "Papadopoulos, G."
Αποτελέσματα 1-20 από 26
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3D protein-protein docking using shape complementarity and fast alignment
(2011)In this paper, a novel approach for fast protein-protein docking based on geometric complementarity is introduced. Complementarity matching is achieved using a rotation-invariant 3D shape descriptor, the Shape Impact ... -
BIOFUNCTIONALIZATION OF PET/SiO2 SURFACES FOR SINGLE MOLECULE EXPERIMENTS AND MEDICAL APPLICATIONS
(2011)PET/SiO2 layers were chemically modified to maintain immobilization of functional single molecules. GFP molecules provide an ideal system due to their stability and intrinsic fluorescence. GFP in vivo biotinylated within ... -
Brain perfusion SPECT with 99mTC-ECD and serum neuron-specific enolase in patients with spontaneous subarachnoid haemorrhage and clinical vasospasm
(2006)Aim: To estimate the association between single photon emission computed tomography (SPECT) imaging and neuro-specific enolase (NSE) serum level measurement in patients with subarachnoid haemorrhage (SAH) and also to present ... -
Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation analysis
(2006)Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional ... -
Clindamycin binding to ribosomes revisited: foot printing and computational detection of two binding sites within the peptidyl transferase center
(2013)Clindamycin is a semi-synthetic lincosamide, active against most Gram-positive bacteria and some protozoa. It binds to the 50S ribosomal subunit and inhibits early peptide chain elongation. By kinetic analysis it has been ... -
Comparison of the blood redox status between long-distance and short-distance runners
(2006)Exercise increases the production of reactive oxygen species, which may damage a number of cell constituents. Organisms have developed a sophisticated antioxidant system for protection against reactive oxygen species. Our ... -
Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol
(2014)Chloramphenicol (CAM) is a broad-spectrum antibiotic, limited to occasional only use in developed countries because of its potential toxicity. To explore the influence of polyamines on the uptake and activity of CAM into ... -
The contribution of the zinc-finger motif to the function of Thermus thermophilus ribosomal protein S14
(2007)In the crystal structure of the 30S ribosomal subunit from Thermus thermophilus, cysteine 24 of ribosomal protein S14 (TthS14) occupies the first position in a CXXC-X12-CXXC motif that coordinates a zinc ion. The structural ... -
Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4 alpha
(2004)Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members ... -
Determination of the number of water molecules in the proton pathway of bacteriorhodopsin using neutron diffraction data
(2003)It has been shown that water molecules participate in the proton pathway of bacteriorhodopsin. Large efforts have been made to determine with various biophysical methods the number of water molecules involved. Neutron ... -
Dimerization of the AtoC response regulator and modelling of its binding to DNA
(2010)Bacterial signal transduction systems can be viewed as an entity of multi-sensory and output domains, whereas the functions of response regulators play a pivotal role in the complex network interactions. One crucial property ... -
"Directed" Cardioplegia: A New Approach in Myocardial Protection in Left Main Coronary Artery Disease
(2008)Directed cardioplegia" is a novel approach in myocardial protection in which a certain volume of cardioplegic solution is diverted into a severely diseased coronary artery after surgical occlusion of the other main branches ... -
Helicobacter pylori neutrophil activating protein as target for new drugs against H. pylori inflammation
(2011)Helicobacter pylori (H. pylon) infection is among the most common human infections and the major risk factor for peptic ulcer disease and gastric cancer. Within this work we present the implication of C-terminal region of ... -
Helicobacter pylori neutrophil-activating protein activates neutrophils by its C-terminal region even without dodecamer formation, which is a prerequisite for DNA protection - novel approaches against Helicobacter pylori inflammation
(2008)Helicobacter pylori neutrophil-activating protein (HP-NAP) protects DNA from free radicals as a dodecamer through its ferroxidase activity without, however, directly binding to it. The retardation that was observed at pH ... -
The impact of stapling devices use on patients with increased body mass index treated with radical cystectomy
(2014)Introduction: The aim of this retrospective study was to evaluate the impact of stapling devices use on overweight and obese bladder cancer patients treated with radical cystectomy (RC). Materials and methods: Fifty-two ... -
Neutron diffraction on purple membranes - Essential water molecules in the light-driven proton pump bacteriorhodopsin
(1997)Neutron diffraction and time-resolved laser-spectroscopic experiments on the light-driven proton-pump bacterio-rhodopsin revealed the location of water molecules and their functional importance. About seven water molecules ... -
On the Intracellular Trafficking of Mouse S5 Ribosomal Protein from Cytoplasm to Nucleoli
(2009)The non-ribosomal functions of mammalian ribosomal proteins have recently attracted worldwide attention. The mouse ribosomal protein S5 (rpS5) derived from ribosomal material is an assembled non-phosphorylated protein. The ... -
On the structural and functional importance of the highly conserved Glu56 of Thermus thermophilus L4 ribosomal protein
(2003)The structural and functional importance of the highly conserved amino acid residue glutamic acid 56 (Glu56) of the ribosomal protein L4 from Thermus thermophilus (TthL4) has been investigated by replacing this residue by ...