Πλοήγηση ανά Συγγραφέα "Georgatsou, E."
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Analysis of molecules differentially interacting with the highly homologous ER-alpha corepressors safb1 and safb2
Tsianou, D.; Lyberopoulou, A.; Kohen, R.; Bonanou, S.; Georgatsou, E. (2006) -
An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1 alpha) Polymorphisms and Osteonecrosis
Chachami, G.; Kalousi, A.; Papatheodorou, L.; Lyberopoulou, A.; Nasikas, V.; Tanimoto, K.; Simos, G.; Malizos, K. N.; Georgatsou, E. (2013)Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1 alpha, the major transcription factor triggered by hypoxia, is ... -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
Chachami, G.; Paraskeva, E.; Georgatsou, E.; Bonanou, S.; Simos, G. (2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B
Nikolakaki, E.; Kohen, R.; Hartmann, A. M.; Stamm, S.; Georgatsou, E.; Giannakouros, T. (2001)Serine/arginine protein kinases have been conserved throughout evolution and are thought to play important roles in the regulation of mRNA processing, nuclear import, germline development, polyamine transport, and ion ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Detection of new molecular partners of hypoxia inducible factor 1 alpha (HIF-1 alpha)
Lyberopoulou, A.; Gadaras, G.; Venieris, E.; Chachami, G.; Simos, G.; Bonanou, S.; Georgatsou, E. (2005) -
Differential regulation of hypoxia inducible factor 1 alpha (HIF-1 alpha) expression and HeLa cell survival and proliferation by hypoxia, desferrioxamine, cobalt and quercetin: the role of iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2005) -
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2
Tsianou, D.; Nikolakaki, E.; Tzitzira, A.; Bonanou, S.; Giannakouros, T.; Georgatsou, E. (2009)SR protein kinases (SRPKs) phosphorylate Ser/Arg dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. Phosphorylation by SRPKs constitutes a major way of regulating such ... -
ERH structurally differentiates between the highly homologous SAFB1 and SAFB2 proteins
Georgatsou, E.; Drakouli, S.; Papathanassiou, M.; Tsianou, D.; Lyberopoulou, A. (2014) -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
Identification of the four most common beta-globin gene mutations in Greek beta-thalassemic patients and carriers by PCR-SSCP: Advantages and limitations of the method
Kakavas, K. V.; Noulas, A.; Chalkias, C.; Hadjichristodoulou, C.; Georgiou, L.; Georgatsou, E.; Bonanou, S. (2006)In the present study we investigated whether the single-strand conformational polymorphism (SSCP) method could be employed to identify (rather than simply detect) the four most common beta-globin gene mutations in the Greek ... -
MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity
Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ... -
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization
Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ... -
Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes
Georgatsou, E.; Alexandraki, D. (1999)The Saccharomyces cerevisiae genome contains nine open reading frames (ORFs) - YLR214w (FRE1), YKL220c (FRE2), YOR381w, YNR060w, YOR384w, YLL051c, YOL152w, YGL160w and YLR047c - which, based on amino acid sequence similarity, ... -
SAFB1 interacts with and suppresses the transcriptional activity of p53
Peidis, P.; Voukkalis, N.; Aggelidou, E.; Georgatsou, E.; Hadzopoulou-Cladaras, M.; Scott, R. E.; Nikolakaki, E.; Giannakouros, T. (2011)A significant amount of nuclear p53 is found associated with the nuclear matrix in cells that were exposed to genotoxic stress. In this study we identified Scaffold attachment factor B1 (SAFB1), a nuclear matrix-associated ... -
Serine-arginine protein kinase 1 (SRPK1) is resilient to nuclear translocation under different metabolic stimuli
Drakouli, S.; Mylonis, I.; Nikolakaki, E.; Giannakouros, T.; Georgatsou, E. (2014) -
Serine-arginine protein kinases: a small protein kinase family with a large cellular presence
Giannakouros, T.; Nikolakaki, E.; Mylonis, I.; Georgatsou, E. (2011)Serine-arginine protein kinases (SPRKs) constitute a relatively novel subfamily of serine-threonine kinases that specifically phosphorylate serine residues residing in serine-arginine/arginine-serine dipeptide motifs. ...