Listar por autor "Pappas, I. S."
Mostrando ítems 1-12 de 12
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Concentrations of clindamycin hydrochloride in homogenates of normal dog skin when administered at two oral dosage regimens
Saridomichelakis, M. N.; Athanasiou, L. V.; Chatzis, M. K.; Salame, M.; Katsoudas, V.; Pappas, I. S. (2013)Background: Clindamycin is frequently used for the treatment of bacterial pyoderma. Objective: To compare the pharmacokinetics of clindamycin in whole skin homogenates of normal dogs when administered orally at two dosage ... -
Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells
Pappas, I. S. (2010)Breast cancer is the second cause of cancer mortality worldwide in humans and half of all tumours in dogs and there is an unmet need for novel anticancer agents. I have developed a new series of aryl ureido derivatives as ... -
The Developmental Program of Murine Erythroleukemia Cells
Tsiftoglou, A. S.; Pappas, I. S.; Vizirianakis, I. S. (2002)Hematopoietic stem cells (HSCs) or early progenitors respond to external stimuli in bone marrow and differentiate into cell-restricted lineages of blood cells of limited life span. In leukemias, however, early hematopoietic ... -
Expression of cytochrome P50s and transcription factors Pxr and Car in canine tissues
Katsiabas, D. S.; Mavridis, S. K.; Pappas, I. S. (2008)Dogs are widely used in the pharmaceutical industry for many study types, including those that will impact decisions on drug development. The purpose of this study was to determine the expression of cytochrome P450 (CYP) ... -
Genetic polymorphism of canine cytochrome P450 2D25 gene
Pappas, I. S.; Katsiabas, D. S. (2004)Human CYP2D6 is involved in the metabolism of a number of drugs including neuroleptics, tricyclic antidepressants, β-adrenoreceptors antagonists and antiarrhythmic drugs. The corresponding canine CYP2D15 have shown similar ... -
Hepatoprotective effect of Pistacia lenticus var. Chia total extract against carbon tetrachloride-induced liver damage in rats
Mavridis, S. K.; Gortzi, O.; Lalas, S.; Paraschos, S.; Skaltsounis, A. L.; Pappas, I. S. (2008) -
Isolation, characterization, and sequencing of nodavirus in sturgeon (Acipenser gueldestaedi L.) reared in freshwater facilities
Xylouri, E.; Kotzamanis, Y. P.; Athanassopoulou, F.; Dong, L.; Pappas, I. S.; Argyrokastritis, A.; Fragkiadaki, E. (2007)The study demonstrates the presence of a nodavirus that affected sturgeon in fresh water, causing disease with neurological signs. The virus was isolated and inoculated onto SSN-1 (striped snakehead, Channa striatus) cell ... -
Mechanisms involved in the induced differentiation of leukemia cells
Tsiftsoglou, A. S.; Pappas, I. S.; Vizirianakis, I. S. (2003)Despite the remarkable progress achieved in the treatment of leukemias over the last several years, many problems (multidrug resistance [MDR], cellular heterogeneity, heterogeneous molecular abnormalities, karyotypic ... -
Mechanisms of action of differentiation inducers: Detection of inducer binding protein(s) in murine erythroleukemia cells
Pappas, I. S.; Lambris, J. D.; Vizirianakis, I. S.; Winters, M. S.; Tsiftsoglou, A. S. (2005)We have shown previously that murine erythroleukemia (MEL) and human neuroectodermal RD/TE-671 cells are induced to differentiate by ureido derivatives of pyridine (UDPs) and may contain inducer binding protein(s). In the ... -
Performance and antioxidant status of broiler chickens supplemented with dried mushrooms (Agaricus bisporus) in their diet
Giannenas, I.; Pappas, I. S.; Mavridis, S.; Kontopidis, G.; Skoufos, J.; Kyriazakis, I. (2010)In this study, we evaluated the growth performance and antioxidant status of broiler chicken supplemented with the edible mushroom Agaricus bisporus. Ninety 1-d-old female broiler chickens randomly allotted to 3 dietary ... -
Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells
Mavridis, S. K.; Pappas, I. S. (2010)Aromatase, the enzyme that coverts testosterone to 17β-estradiol, has attracted attention lately because of its involvement in some forms of breast cancer in women. Studies are now undergoing on a variety of species to ... -
Serum pharmacokinetics of clindamycin hydrochloride in normal dogs when administered at two dosage regimens
Saridomichelakis, M. N.; Athanasiou, L. V.; Salame, M.; Chatzis, M. K.; Katsoudas, V.; Pappas, I. S. (2011)The aim of this cross-over study was to compare clindamycin pharmacokinetics in the serum of clinically normal dogs when administered orally at two dosage regimens (5.5 mg/kg, twice daily, and 11 mg/kg, once daily), separated ...