How can we effectively address the paraneoplastic dermatomyositis: Diagnosis, risk factors and treatment options

Zerdes I., Tolia M., Nikolaou M., Tsoukalas N., Velentza L., Hajiioannou J., Mitsis M., Kyrgias G.

dc.creator	Zerdes I., Tolia M., Nikolaou M., Tsoukalas N., Velentza L., Hajiioannou J., Mitsis M., Kyrgias G.	en
dc.date.accessioned	2023-01-31T11:38:23Z
dc.date.available	2023-01-31T11:38:23Z
dc.date.issued	2017
dc.identifier.issn	11070625
dc.identifier.uri	http://hdl.handle.net/11615/80969
dc.description.abstract	Purpose: Dermatomyositis (DM) represents an auto-immune inflammatory myopathy. In this review, we analyzed the incidence of DM as a clinical manifestation highlighting the peculiar clinical and treatment characteristics of this disease when occurring in the context of different malignancies. Methods: A systematic literature review was performed based on database search in PubMed/Medline and included English articles until December 2016. Results: In up to 20% of cases DM appears as a paraneoplastic syndrome associated with multiple malignancies such as ovarian, breast, prostate, lung, nasopharyngeal and colorectal cancer, and non-Hodgkin lymphomas. It can be presented either before, in the time, or after cancer diagnosis. Systemic sclerosis and mixed connective-tissue disease represent common coinciding disorders. Particular caution should be given in the radiotherapy because the microvascular endothelial radiation damage and autoimmune inflammatory collagen vascular disease caused by DM may be additive. There is a higher risk of late toxicity in the presence of other concurrent vascular diseases, including diabetes, hypertension or administration of chemotherapy. Prednisone represents the first-line treatment option but immunosuppressive drugs such as azathioprine and methotrexate may also be incorporated in the therapeutic armamentarium especially when DM is associated with malignancy. Intravenous immunoglobulin could be a promising alternative in prednisone-resistant cases. The effectiveness of therapies with antigen-specific agents such as monoclonal antibodies is currently under investigation. Conclusions: Timely diagnosis coupled with a treatment plan focused on muscular endurance and improvement of skin lesions and other symptoms offer a favorable response to therapy along with the achievement of a higher quality of life for these patients. © 2017 Zerbinis Publications. All rights reserved.	en
dc.language.iso	en	en
dc.source	Journal of B.U.ON.	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045548940&partnerID=40&md5=b45338190da02b46a639ee2bb2f3745a
dc.subject	azathioprine	en
dc.subject	immunoglobulin	en
dc.subject	methotrexate	en
dc.subject	monoclonal antibody	en
dc.subject	prednisone	en
dc.subject	antiinflammatory agent	en
dc.subject	autoinflammatory disease	en
dc.subject	breast cancer	en
dc.subject	cancer radiotherapy	en
dc.subject	collagen disease	en
dc.subject	colonoscopy	en
dc.subject	colorectal cancer	en
dc.subject	computer assisted tomography	en
dc.subject	dermatomyositis	en
dc.subject	diabetes mellitus	en
dc.subject	disease association	en
dc.subject	drug efficacy	en
dc.subject	human	en
dc.subject	hypertension	en
dc.subject	immunosuppressive treatment	en
dc.subject	laboratory test	en
dc.subject	lung cancer	en
dc.subject	mixed connective tissue disease	en
dc.subject	nasopharynx cancer	en
dc.subject	nonhodgkin lymphoma	en
dc.subject	ovary cancer	en
dc.subject	paraneoplastic syndrome	en
dc.subject	physical examination	en
dc.subject	prostate cancer	en
dc.subject	radiation injury	en
dc.subject	Review	en
dc.subject	risk factor	en
dc.subject	systematic review	en
dc.subject	systemic sclerosis	en
dc.subject	thorax radiography	en
dc.subject	treatment response	en
dc.subject	vascular disease	en
dc.subject	clinical trial (topic)	en
dc.subject	dermatomyositis	en
dc.subject	meta analysis	en
dc.subject	neoplasm	en
dc.subject	paraneoplastic syndrome	en
dc.subject	randomized controlled trial (topic)	en
dc.subject	Anti-Inflammatory Agents	en
dc.subject	Clinical Trials as Topic	en
dc.subject	Dermatomyositis	en
dc.subject	Humans	en
dc.subject	Neoplasms	en
dc.subject	Paraneoplastic Syndromes	en
dc.subject	Prednisone	en
dc.subject	Randomized Controlled Trials as Topic	en
dc.subject	Risk Factors	en
dc.subject	Zerbinis Publications	en
dc.title	How can we effectively address the paraneoplastic dermatomyositis: Diagnosis, risk factors and treatment options	en
dc.type	other	en

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Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
Competing mortality in patients with neuroendocrine tumors

Low S.K., Giannis D., Bahaie N.S., Trong B.L.H., Moris D., Huy N.T. (2019)

Objectives: Patients with neuroendocrine tumors (NETs) are at increased risk of mortality from competing causes in light of the improvement in overall survival over recent decades. The purpose of this study was to explore ...

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