dc.creator | Zarogiannis S.G., Kalomenidis I. | en |
dc.date.accessioned | 2023-01-31T11:38:19Z | |
dc.date.available | 2023-01-31T11:38:19Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1097/MCP.0000000000000170 | |
dc.identifier.issn | 10705287 | |
dc.identifier.uri | http://hdl.handle.net/11615/80959 | |
dc.description.abstract | Purpose of review Pleural effusion is a common clinical problem resulting from a wide range of diseases. Treatment options include targeting the primary cause or, in persistent cases, invasive removal of the excess fluid from the pleural cavity. In this review, we summarize the experimental data concerning pharmacological agents that influence pleural fluid resorption and examine their potential as a novel noninvasive treatment strategy. Recent findings Recently published evidence indicates that adrenergic agents and corticosteroids can increase pleural fluid clearance from the cavity. On the contrary, paracetamol and certain nonsteroid anti-inflammatory drugs can impede fluid outflow. These concepts are based on data extracted by in-vivo studies using provoked hydrothoraces in rabbits and mice, as well as by ex-vivo electrophysiological experiments using sheep and human pleural tissue. Summary In conclusion, the available experimental data indicate that certain pharmacological agents may impact fluid resorption, thus affecting pleural fluid accumulation and the rate of pleural effusion resolution. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Current Opinion in Pulmonary Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942916432&doi=10.1097%2fMCP.0000000000000170&partnerID=40&md5=608142a1ed0c607d224c724838dfb6bd | |
dc.subject | adrenergic receptor stimulating agent | en |
dc.subject | antiinflammatory agent | en |
dc.subject | corticosteroid | en |
dc.subject | nonsteroid antiinflammatory agent | en |
dc.subject | paracetamol | en |
dc.subject | adrenergic stimulation | en |
dc.subject | electrophysiological procedures | en |
dc.subject | human | en |
dc.subject | mesothelium cell | en |
dc.subject | non invasive procedure | en |
dc.subject | nonhuman | en |
dc.subject | pleura cavity | en |
dc.subject | pleura fluid | en |
dc.subject | pleural fluid resorption | en |
dc.subject | Review | en |
dc.subject | turnover time | en |
dc.subject | animal | en |
dc.subject | complication | en |
dc.subject | exudate | en |
dc.subject | hydrothorax | en |
dc.subject | Pleural Effusion | en |
dc.subject | Adrenal Cortex Hormones | en |
dc.subject | Animals | en |
dc.subject | Exudates and Transudates | en |
dc.subject | Humans | en |
dc.subject | Hydrothorax | en |
dc.subject | Pleural Cavity | en |
dc.subject | Pleural Effusion | en |
dc.subject | Lippincott Williams and Wilkins | en |
dc.title | Can pharmacologic agents speed the rate of resorption of pleural fluid? | en |
dc.type | other | en |