dc.creator | Velentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G. | en |
dc.date.accessioned | 2023-01-31T10:31:22Z | |
dc.date.available | 2023-01-31T10:31:22Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 11070625 | |
dc.identifier.uri | http://hdl.handle.net/11615/80558 | |
dc.description.abstract | Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. Methods: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We selected studies which focused on children patients (<18 yr old) with brain tumors treated with radiotherapy and the consequences for their endocrine system. Results: Growth hormone (GH) deficiency was the most common post-irradiation abnormality among children cancer survivors, followed by gonadotrophin (GT), thyroid stimulating hormone (TSH), corticotropin (ACTH) and prolactin (PRL) disorders. Conclusions: The age of the patient, total radiotherapy dose, number of fractions, fraction size and the duration of treatment seem to determine the severity of these disturbances. © 2017 Zerbinis Publications. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Journal of B.U.ON. | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045557849&partnerID=40&md5=833ee3eaaee05171630deaf7b47d5dd9 | |
dc.subject | brain radiation | en |
dc.subject | brain tumor | en |
dc.subject | cancer radiotherapy | en |
dc.subject | childhood cancer survivor | en |
dc.subject | childhood disease | en |
dc.subject | clinical assessment | en |
dc.subject | corticotropin deficiency | en |
dc.subject | disease severity | en |
dc.subject | follitropin disorder | en |
dc.subject | gonadotropin deficiency | en |
dc.subject | growth hormone deficiency | en |
dc.subject | hormone deficiency | en |
dc.subject | hormone release | en |
dc.subject | human | en |
dc.subject | hypothalamus hypophysis system | en |
dc.subject | irradiation | en |
dc.subject | luteinizing hormone disorde | en |
dc.subject | prolactin disorder | en |
dc.subject | radiation injury | en |
dc.subject | Review | en |
dc.subject | systematic review | en |
dc.subject | thyrotropin disorder | en |
dc.subject | adolescent | en |
dc.subject | brain tumor | en |
dc.subject | child | en |
dc.subject | complication | en |
dc.subject | female | en |
dc.subject | hypophysis | en |
dc.subject | hypothalamus | en |
dc.subject | male | en |
dc.subject | pathology | en |
dc.subject | preschool child | en |
dc.subject | radiation injury | en |
dc.subject | radiation response | en |
dc.subject | Adolescent | en |
dc.subject | Brain Neoplasms | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Hypothalamus | en |
dc.subject | Male | en |
dc.subject | Pituitary Gland | en |
dc.subject | Radiation Injuries | en |
dc.subject | Zerbinis Publications | en |
dc.title | Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients | en |
dc.type | other | en |