dc.creator | Vavougios G.D., Solenov E.I., Hatzoglou C., Baturina G.S., Katkova L.E., Molyvdas P.A., Gourgoulianis K.I., Zarogiannis S.G. | en |
dc.date.accessioned | 2023-01-31T10:30:39Z | |
dc.date.available | 2023-01-31T10:30:39Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1152/ajplung.00051.2015 | |
dc.identifier.issn | 10400605 | |
dc.identifier.uri | http://hdl.handle.net/11615/80537 | |
dc.description.abstract | The aim of our study was to assess the differential gene expression of Parkinson protein 7 (PARK7) interactome in malignant pleural mesothelioma (MPM) using data mining techniques to identify novel candidate genes that may play a role in the pathogenicity of MPM. We constructed the PARK7 interactome using the ConsensusPathDB database. We then interrogated the Oncomine Cancer Microarray database using the Gordon Mesothelioma Study, for differential gene expression of the PARK7 interactome. In ConsensusPathDB, 38 protein interactors of PARK7 were identified. In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2). Furthermore, Kaplan-Meier analysis revealed that MPM patients with high BBS1 expression had a median overall survival of 16.5 vs. 8.7 mo of those that had low expression. For validation purposes, we performed a meta-analysis in Oncomine database in five sarcoma datasets. Eight network 2 genes (KIAA0101, HDAC2, SUMO1, RBBP4, NONO, RBBP7, HTRA2, and MTA2) were significantly differentially expressed in an array of 18 different sarcoma types. Finally, Gene Ontology annotation enrichment analysis revealed significant roles of the PARK7 interactome in NuRD, CHD, and SWI/ SNF protein complexes. In conclusion, we identified 13 novel genes differentially expressed in MPM, never reported before. Among them, BBS1 emerged as a novel predictor of overall survival in MPM. Finally, we identified that PARK7 interactome is involved in novel pathways pertinent in MPM disease. © 2015 the American Physiological Society. | en |
dc.language.iso | en | en |
dc.source | American Journal of Physiology - Lung Cellular and Molecular Physiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943279368&doi=10.1152%2fajplung.00051.2015&partnerID=40&md5=a07816e127f087e6ea05cab1c72d8b00 | |
dc.subject | bardet biedl syndrome 1 protein | en |
dc.subject | cell division cycle 34 | en |
dc.subject | Daxx protein | en |
dc.subject | DJ 1 protein | en |
dc.subject | histone deacetylase 2 | en |
dc.subject | nonpou domain containing octamer binding | en |
dc.subject | pcna associated factor | en |
dc.subject | peptides and proteins | en |
dc.subject | protein | en |
dc.subject | retinoblastoma binding protein 4 | en |
dc.subject | retinoblastoma binding protein 7 | en |
dc.subject | serine proteinase Omi | en |
dc.subject | stip1 homology and u box containing protein 1 e3 ubiquitin protein ligase | en |
dc.subject | SUMO 1 protein | en |
dc.subject | tumor necrosis factor receptor associated factor 6 | en |
dc.subject | unclassified drug | en |
dc.subject | Bbs1 protein, human | en |
dc.subject | microtubule associated protein | en |
dc.subject | oncoprotein | en |
dc.subject | PARK7 protein, human | en |
dc.subject | signal peptide | en |
dc.subject | tumor protein | en |
dc.subject | Article | en |
dc.subject | cancer genetics | en |
dc.subject | cancer survival | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | gene expression | en |
dc.subject | genetic analysis | en |
dc.subject | human | en |
dc.subject | overall survival | en |
dc.subject | pathogenicity | en |
dc.subject | pleura mesothelioma | en |
dc.subject | priority journal | en |
dc.subject | survival time | en |
dc.subject | biology | en |
dc.subject | biosynthesis | en |
dc.subject | data mining | en |
dc.subject | disease free survival | en |
dc.subject | female | en |
dc.subject | gene expression regulation | en |
dc.subject | gene regulatory network | en |
dc.subject | genetic database | en |
dc.subject | genetics | en |
dc.subject | male | en |
dc.subject | mesothelioma | en |
dc.subject | metabolism | en |
dc.subject | mortality | en |
dc.subject | pleura tumor | en |
dc.subject | procedures | en |
dc.subject | survival rate | en |
dc.subject | Computational Biology | en |
dc.subject | Data Mining | en |
dc.subject | Databases, Genetic | en |
dc.subject | Disease-Free Survival | en |
dc.subject | Female | en |
dc.subject | Gene Expression Regulation, Neoplastic | en |
dc.subject | Gene Regulatory Networks | en |
dc.subject | Humans | en |
dc.subject | Intracellular Signaling Peptides and Proteins | en |
dc.subject | Male | en |
dc.subject | Mesothelioma | en |
dc.subject | Microtubule-Associated Proteins | en |
dc.subject | Neoplasm Proteins | en |
dc.subject | Oncogene Proteins | en |
dc.subject | Pleural Neoplasms | en |
dc.subject | Survival Rate | en |
dc.subject | American Physiological Society | en |
dc.title | Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma | en |
dc.type | journalArticle | en |