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Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a

dc.creatorVavougios G.D., Mavridis T., Artemiadis A., Krogfelt K.A., Hadjigeorgiou G.en
dc.date.accessioned2023-01-31T10:30:27Z
dc.date.available2023-01-31T10:30:27Z
dc.date.issued2022
dc.identifier10.1016/j.bbadis.2022.166430
dc.identifier.issn09254439
dc.identifier.urihttp://hdl.handle.net/11615/80532
dc.description.abstractType I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections. © 2022 Elsevier B.V.en
dc.language.isoenen
dc.sourceBiochimica et Biophysica Acta - Molecular Basis of Diseaseen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85129968384&doi=10.1016%2fj.bbadis.2022.166430&partnerID=40&md5=01ef8009970fb3319681bbff03e6eba7
dc.subjectbeta1a interferonen
dc.subjectinterferon inducible transmembrane protein 3en
dc.subjectmembrane proteinen
dc.subjectoligoadenylate synthetase 1en
dc.subjectunclassified drugen
dc.subjectbeta interferonen
dc.subjectAlzheimer diseaseen
dc.subjectcoronavirus disease 2019en
dc.subjectepigeneticsen
dc.subjecthumanen
dc.subjectimmunological memoryen
dc.subjectimmunomodulationen
dc.subjectinnate immunityen
dc.subjectmultiple sclerosisen
dc.subjectnervous system inflammationen
dc.subjectReviewen
dc.subjecttype I interferon signalingen
dc.subjectvirus immunityen
dc.subjectvirus infectionen
dc.subjectAlzheimer Diseaseen
dc.subjectCOVID-19en
dc.subjectHumansen
dc.subjectInterferon-betaen
dc.subjectMultiple Sclerosisen
dc.subjectVirus Diseasesen
dc.subjectElsevier B.V.en
dc.titleTrained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1aen
dc.typeotheren


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