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The putative interplay between DJ-1/NRF2 and Dimethyl Fumarate: A potentially important pharmacological target

dc.creatorVavougios G., Zarogiannis S.G., Doskas T.en
dc.date.accessioned2023-01-31T10:29:56Z
dc.date.available2023-01-31T10:29:56Z
dc.date.issued2018
dc.identifier10.1016/j.msard.2018.02.027
dc.identifier.issn22110348
dc.identifier.urihttp://hdl.handle.net/11615/80518
dc.description.abstractRecent research has outlined that Dimethyl Fumarate (DMF) functions as a gene regulator via multiple pathways, critical among which is the NRF2 cytoprotective cascade. PARK7/DJ-1 is a multifunctional protein that acts as a redox sensor and effector of multiple cytoprotective pathways, including NRF2. Specifically, it prevents the association of NRF2 with its inhibitor KEAP1, allowing NRF2 to enter the nucleus and mediate cytoprotective and antioxidant cascades. It is our hypothesis that while the NRF2-KEAP1 inhibitory complex is reported the main pharmacological target for DMF's NRF dependent functions, no study to date has explored the effects of DMF on DJ-1's expression, and vice-versa, the possibility of a regulatory inadequacy in the upstream, oxidant-responsive DJ-1 activator of the NRF2 cascade. © 2018 Elsevier B.V.en
dc.language.isoenen
dc.sourceMultiple Sclerosis and Related Disordersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85043376966&doi=10.1016%2fj.msard.2018.02.027&partnerID=40&md5=c84fca1ec5ddeaeccb734b2ef83b3e68
dc.subjectchemokine receptor CXCR4en
dc.subjectfumaric acid dimethyl esteren
dc.subjectimmunoglobulin enhancer binding proteinen
dc.subjectmammalian target of rapamycinen
dc.subjectphosphatidylinositol 3 kinaseen
dc.subjectphosphatidylinositol 3,4,5 trisphosphate 3 phosphataseen
dc.subjectprotein deglycase DJ-1en
dc.subjectreactive oxygen metaboliteen
dc.subjecttranscription factor Nrf2en
dc.subjectfumaric acid dimethyl esteren
dc.subjectimmunosuppressive agenten
dc.subjectprotein deglycase DJ-1en
dc.subjecttranscription factor Nrf2en
dc.subjectcell fateen
dc.subjectcellular immunityen
dc.subjectcytokine responseen
dc.subjectdemyelinating diseaseen
dc.subjectdisease associationen
dc.subjecthumanen
dc.subjectimmune responseen
dc.subjectimmunomodulationen
dc.subjectmalignant neoplasmen
dc.subjectnonhumanen
dc.subjectoxidative stressen
dc.subjectprotein bindingen
dc.subjectprotein expressionen
dc.subjectprotein functionen
dc.subjectprotein protein interactionen
dc.subjectprotein targetingen
dc.subjectReviewen
dc.subjectsignal transductionen
dc.subjectanimalen
dc.subjectmetabolismen
dc.subjectmultiple sclerosisen
dc.subjectneoplasmen
dc.subjectAnimalsen
dc.subjectDimethyl Fumarateen
dc.subjectHumansen
dc.subjectImmunosuppressive Agentsen
dc.subjectMultiple Sclerosisen
dc.subjectNeoplasmsen
dc.subjectNF-E2-Related Factor 2en
dc.subjectProtein Deglycase DJ-1en
dc.subjectElsevier B.V.en
dc.titleThe putative interplay between DJ-1/NRF2 and Dimethyl Fumarate: A potentially important pharmacological targeten
dc.typeotheren


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