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dc.creatorVaritimidis S.E., Dailiana Z.H., Christou D., Grafanaki K., Ioannou M.G., Stathopoulos C., Malizos K.N.en
dc.date.accessioned2023-01-31T10:26:30Z
dc.date.available2023-01-31T10:26:30Z
dc.date.issued2016
dc.identifier.issn00016462
dc.identifier.urihttp://hdl.handle.net/11615/80407
dc.description.abstractThis study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydroxyproline content and attempts to correlate these fndings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed. Hydroxyprolin presence was evaluated in various tissues. Mean follow-up was 46 months. Histological analysis revealed collagen fragmentation and thinning (90.2% of patients), myxoid degeneration (88%), hyaline degeneration (50.8%), chondroid metaplasia (44.3%), calcifcation (24.7%), fatty infltration (20.4%) and vascular proliferation (62.3%). Hydroxyproline was under-represented in newly synthesized collagen in 57% of patients. In the majority of the patients with a low hydroxyproline/collagen ratio the histological fndings were abnormal. None of the fndings was related to the clinical outcome with a statistical signifcance. Histological and biochemical fndings re?ected the poor quality of the tendon. The good clinical outcome did not depend on the histological or biochemical fndings but rather on the meticulous surgical reconstruction and physical therapy. © 2016, Acta Orthopedica Belgica.en
dc.language.isoenen
dc.sourceActa Orthopaedica Belgicaen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84990036949&partnerID=40&md5=3fc82ac3ea72f09c38c99d6fd9a2f0c1
dc.subjectcollagenen
dc.subjecthydroxyprolineen
dc.subjectadulten
dc.subjectageden
dc.subjectbiosynthesisen
dc.subjectfemaleen
dc.subjecthumanen
dc.subjectmaleen
dc.subjectmetabolismen
dc.subjectmiddle ageden
dc.subjectpathologyen
dc.subjectRotator Cuff Injuriesen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCollagenen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHydroxyprolineen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRotator Cuff Injuriesen
dc.subjectARSMB-KVBMGen
dc.titleHistological and biochemical evidence related to the collagen quality in torn rotator cuff tendonsen
dc.typejournalArticleen


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