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Simulation to minimise patient self-inflicted lung injury: are we almost there?

dc.creatorTsolaki V., Zakynthinos G.E.en
dc.date.accessioned2023-01-31T10:17:19Z
dc.date.available2023-01-31T10:17:19Z
dc.date.issued2022
dc.identifier10.1016/j.bja.2022.05.007
dc.identifier.issn00070912
dc.identifier.urihttp://hdl.handle.net/11615/80084
dc.description.abstractComputational modelling has been used to enlighten pathophysiological issues in patients with acute respiratory distress syndrome (ARDS) using a sophisticated, integrated cardiopulmonary model. COVID-19 ARDS is a pathophysiologically distinct entity characterised by dissociation between impairment in gas exchange and respiratory system mechanics, especially in the early stages of ARDS. Weaver and colleagues used computational modelling to elucidate factors contributing to generation of patient self-inflicted lung injury, and evaluated the effects of various spontaneous respiratory efforts with different oxygenation and ventilatory support modes. Their findings indicate that mechanical forces generated in the lung parenchyma are only counterbalanced when the respiratory support mode reduces the intensity of respiratory efforts. © 2022 British Journal of Anaesthesiaen
dc.language.isoenen
dc.sourceBritish Journal of Anaesthesiaen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85132514695&doi=10.1016%2fj.bja.2022.05.007&partnerID=40&md5=2361ae0e91417c748540ad6b56168eb0
dc.subjectadult respiratory distress syndromeen
dc.subjectartificial ventilationen
dc.subjectassisted ventilationen
dc.subjectatelectasisen
dc.subjectclinical researchen
dc.subjectcomputer modelen
dc.subjectcomputer simulationen
dc.subjectcontinuous positive airway pressureen
dc.subjectcoronavirus disease 2019en
dc.subjectEditorialen
dc.subjectground glass opacityen
dc.subjecthigh flow nasal cannula therapyen
dc.subjecthypoxemiaen
dc.subjecthypoxic lung vasoconstrictionen
dc.subjectlung complianceen
dc.subjectlung gas exchangeen
dc.subjectlung injuryen
dc.subjectlung mechanicsen
dc.subjectlung parenchymaen
dc.subjectmathematical modelen
dc.subjectoxygen therapyen
dc.subjectoxygenationen
dc.subjectpathophysiologyen
dc.subjectpatient self inflicted lung injuryen
dc.subjectpositive end expiratory pressure ventilationen
dc.subjectpredictive validityen
dc.subjectproportional assist ventilationen
dc.subjectprotective ventilationen
dc.subjectthrombusen
dc.subjecttidal volumeen
dc.subjectventilator induced lung injuryen
dc.subjectvolutraumaen
dc.subjectbreathing mechanicsen
dc.subjectcomputer simulationen
dc.subjecthumanen
dc.subjectlungen
dc.subjectphysiologyen
dc.subjectrespiratory distress syndromeen
dc.subjectComputer Simulationen
dc.subjectCOVID-19en
dc.subjectHumansen
dc.subjectLungen
dc.subjectLung Injuryen
dc.subjectPositive-Pressure Respirationen
dc.subjectRespiration, Artificialen
dc.subjectRespiratory Distress Syndromeen
dc.subjectRespiratory Mechanicsen
dc.subjectElsevier Ltden
dc.titleSimulation to minimise patient self-inflicted lung injury: are we almost there?en
dc.typeotheren


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