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dc.creatorTsapanou A., Mourtzi N., Charisis S., Hatzimanolis A., Ntanasi E., Kosmidis M.H., Yannakoulia M., Hadjigeorgiou G., Dardiotis E., Sakka P., Stern Y., Scarmeas N.en
dc.date.accessioned2023-01-31T10:11:44Z
dc.date.available2023-01-31T10:11:44Z
dc.date.issued2022
dc.identifier10.3390/genes13010063
dc.identifier.issn20734425
dc.identifier.urihttp://hdl.handle.net/11615/79856
dc.description.abstractSleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, ApolipoproteinE-ε4 genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, p = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, p = 0.018) and the adjusted for the covariates model (B = −1273.59, p = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, p = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.sourceGenesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85121989155&doi=10.3390%2fgenes13010063&partnerID=40&md5=75a01a40030ecff6dba8da625aa035a4
dc.subjectageen
dc.subjectageden
dc.subjectAPOE epsilon 4 geneen
dc.subjectArticleen
dc.subjectattentionen
dc.subjectcognitionen
dc.subjectcontrolled studyen
dc.subjectdemographicsen
dc.subjectdepth perceptionen
dc.subjecteducationen
dc.subjectexecutive functionen
dc.subjectfemaleen
dc.subjectfollow upen
dc.subjectgeneen
dc.subjectgenetic risk scoreen
dc.subjectgeneticsen
dc.subjectgenome-wide association studyen
dc.subjectgenotypeen
dc.subjecthumanen
dc.subjecthuman experimenten
dc.subjectlanguageen
dc.subjectmaleen
dc.subjectmedical historyen
dc.subjectmemoryen
dc.subjectnormal humanen
dc.subjectphysical examinationen
dc.subjectprocessing speeden
dc.subjectself reporten
dc.subjectsexen
dc.subjectsleepen
dc.subjectsleep polygenic risk scoreen
dc.subjectsleep timeen
dc.subjectstructured interviewen
dc.subjectagingen
dc.subjectcognitive defecten
dc.subjectcomplicationen
dc.subjectgeneticsen
dc.subjectgenome-wide association studyen
dc.subjectlongitudinal studyen
dc.subjectmetabolismen
dc.subjectneuropsychological testen
dc.subjectpathologyen
dc.subjectrisk factoren
dc.subjectsleepen
dc.subjectsleep disorderen
dc.subjecttime factoren
dc.subjectAgeden
dc.subjectAgingen
dc.subjectCognitive Dysfunctionen
dc.subjectFemaleen
dc.subjectGenome-Wide Association Studyen
dc.subjectHumansen
dc.subjectLongitudinal Studiesen
dc.subjectMaleen
dc.subjectNeuropsychological Testsen
dc.subjectRisk Factorsen
dc.subjectSleepen
dc.subjectSleep Wake Disordersen
dc.subjectTime Factorsen
dc.subjectMDPIen
dc.titleSleep polygenic risk score is associated with cognitive changes over timeen
dc.typejournalArticleen


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