dc.creator | Triantafyllou C., Kourkouni E., Gkentzi D., Gouvias T., Dimitriou G., Doganis D., Kaisari A., Kapetanaki A., Karavana G., Karachristou K., Kontou A., Kourlaba G., Kopsidas Ι., Lithoxopoulou Μ., Molocha N.M., Bouza E., Nikolaou F., Papakonstantinou E., Polychronaki M., Polychronopoulou S., Raptis K., Roilides E., Sdougka Μ., Stratiki Ε., Syrogiannopoulos G., Tataropoulou K., Tragiannidis A., Triantafyllidou P., Tsipou H., Tsirogianni C., Tsopela G.C., Hatzipantelis E., Chorafa E., Chorianopoulou E., Zaoutis T. | en |
dc.date.accessioned | 2023-01-31T10:09:50Z | |
dc.date.available | 2023-01-31T10:09:50Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 11053992 | |
dc.identifier.uri | http://hdl.handle.net/11615/79771 | |
dc.description.abstract | ΟBJECTIVE To provide updated data on the rates of central line-associated bloodstream infections (CLABSI) in Greek neonatal intensive care units (NICUs), pediatric intensive care units (PICUs) and pediatric oncology units (PONCs), and to describe pathogen distribution and antimicrobial resistance patterns for CLABSIs. METHOD Active surveillance for CLABSI was conducted from June 2016 to December 2019 (43 months). A consortium of 14 NICUs, 3 PICUs, and 6 PONCs participated in the program. Surveillance definitions of central line (CL), central line utilization (CLU) ratio, CLABSI event, and CLABSI rate were based on the 2014 National Healthcare Safety Network criteria of the US Centers for Disease Control and Prevention (CDC). Medical records were assessed daily for calculation of CL-days, pa-tient-days, and susceptibility to isolated organisms. RESULTS A total of 519 CLABSI episodes were recorded in the 43 months. Mean CLABSI rates were 7.15 in NICUs, 5.19 in PICUs, and 2.20, per 1,000 CL-days in PONCs. A higher mean CLU ratio was reported in PONCs (0.83) and a lower mean ratio was found in NICUs (0.15). A total of 567 pathogens were isolated, the most common of which were Enterobacterales (42.1%), followed by Gram-positive cocci (29%), non-fermenting Gram-negative bacteria (14.6%), and fungi (11.5%). Among 239 (63.1%) Enterobacterales isolated, 151 were multidrug resistant. Overall, 14.8% of Gram-negative pathogens were resistant to third generation ceph-alosporins and 23.7% to carbapenems. CONCLUSIONS The rates of CLABSI and antibiotic resistance among organ-isms causing CLABSI are high in high-risk hospitalized children. These data highlight the significance of this problem and emphasize the need for implementation of infection prevention interventions. The methodology used for this surveillance program could be applied in other pediatric or adult units across Greece. © Athens Medical Society. | en |
dc.language.iso | el | en |
dc.source | Archives of Hellenic Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128359046&partnerID=40&md5=b92fac6b183af669163e6d3408fee1fb | |
dc.subject | carbapenem | en |
dc.subject | cephalosporin | en |
dc.subject | antibiotic resistance | en |
dc.subject | Article | en |
dc.subject | bacterium isolation | en |
dc.subject | catheter infection | en |
dc.subject | clinical article | en |
dc.subject | Enterobacterales | en |
dc.subject | fungus | en |
dc.subject | Gram negative bacterium | en |
dc.subject | Gram positive cocci | en |
dc.subject | health program | en |
dc.subject | human | en |
dc.subject | national nosocomial infections surveillance program | en |
dc.subject | neonatal intensive care unit | en |
dc.subject | BETA Medical Publishers Ltd | en |
dc.title | Central line-associated bloodstream infections in pediatric patients: Results from a national nosocomial infections surveillance program | en |
dc.type | journalArticle | en |