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dc.creatorSyrogiannopoulos G.A., Michoula A.N., Petinaki E., Grivea I.N.en
dc.date.accessioned2023-01-31T10:05:20Z
dc.date.available2023-01-31T10:05:20Z
dc.date.issued2017
dc.identifier10.1097/INF.0000000000001629
dc.identifier.issn08913668
dc.identifier.urihttp://hdl.handle.net/11615/79557
dc.description.abstractBackground: In Greece, there are high rates of methicillin (40%-60%) and clindamycin (15%-25%) resistance among community-acquired Staphylococcus aureus isolates. Therefore, we sought to identify other antimicrobial treatment options such as daptomycin. Methods: We studied retrospectively all pediatric infections treated with daptomycin at the University General Hospital of Larissa, Greece, from January 1, 2007, to June 16, 2016. Results: Of a total of 128 patients (median age: 2.8 years; range: 8 days to 14.5 years; 76.6% <7 years) treated with daptomycin, 45 (35.2%) had invasive infection, most frequently musculoskeletal, and 83 (64.8%) had noninvasive infection, that is, complicated skin and soft tissue infection. S. aureus was the most commonly recovered pathogen (n = 61) (63.9% methicillin-resistant isolates, 21.3% clindamycin-resistant). The average daily dose of daptomycin was 10 mg/kg qd, and the median duration of therapy was 10 days. Daptomycin was administered alone (n = 61) or in combination therapy (n = 67), most frequently with rifampin (n = 40) and/or a β-lactam antibiotic (n = 33). Open or closed drainage was performed in 86 (67.2%) of the total number of patients. Of 128 treated patients, 123 (96.1%) achieved clinical success, 114 (89.1%) had complete remission, and 9 (7%) had improvement of their disease. There were no failures with daptomycin therapy. The adverse events were of no clinical significance. Conclusions: Daptomycin administered alone or in combination with other antimicrobial agents to children was efficacious and well tolerated in the treatment of complicated infections of suspected or proven staphylococcal etiology. © 2017 Wolters Kluwer Health, Inc. All rights reserved.en
dc.language.isoenen
dc.sourcePediatric Infectious Disease Journalen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030615162&doi=10.1097%2fINF.0000000000001629&partnerID=40&md5=796ab2a1c9483d9c196e9e6efc2e5158
dc.subjectaminopenicillinen
dc.subjectampicillinen
dc.subjectaztreonamen
dc.subjectbeta lactamen
dc.subjectcefotaximeen
dc.subjectcephalosporinen
dc.subjectclindamycinen
dc.subjectdaptomycinen
dc.subjectmeropenemen
dc.subjectquinolone derivativeen
dc.subjectrifampicinen
dc.subjectantiinfective agenten
dc.subjectdaptomycinen
dc.subjectabscessen
dc.subjectadolescenten
dc.subjectantibiotic therapyen
dc.subjectarthritisen
dc.subjectArticleen
dc.subjectchilden
dc.subjectclinical outcomeen
dc.subjectclosed drainageen
dc.subjectcombination drug therapyen
dc.subjectcommunity acquired infectionen
dc.subjectdrug tolerabilityen
dc.subjectfemaleen
dc.subjectGreeceen
dc.subjectgroups by ageen
dc.subjecthospital infectionen
dc.subjecthumanen
dc.subjectinfanten
dc.subjectinfectionen
dc.subjectlymphadenitisen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmedical record reviewen
dc.subjectmethicillin resistant Staphylococcus aureusen
dc.subjectmonotherapyen
dc.subjectmusculoskeletal infectionen
dc.subjectnewbornen
dc.subjectnonhumanen
dc.subjectorbit cellulitisen
dc.subjectosteomyelitisen
dc.subjectpatient safetyen
dc.subjectpreschool childen
dc.subjectpriority journalen
dc.subjectpyomyositisen
dc.subjectremissionen
dc.subjectretrospective studyen
dc.subjectskin infectionen
dc.subjectsoft tissue infectionen
dc.subjectStaphylococcus infectionen
dc.subjecttreatment durationen
dc.subjectBacterial Infectionsen
dc.subjectmicrobiologyen
dc.subjectMuscular Diseasesen
dc.subjectSoft Tissue Infectionsen
dc.subjecttreatment outcomeen
dc.subjectAdolescenten
dc.subjectAnti-Bacterial Agentsen
dc.subjectBacterial Infectionsen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDaptomycinen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectMuscular Diseasesen
dc.subjectRetrospective Studiesen
dc.subjectSoft Tissue Infectionsen
dc.subjectTreatment Outcomeen
dc.subjectLippincott Williams and Wilkinsen
dc.titleDaptomycin Use in Children: Experience with Various Types of Infection and Age Groupsen
dc.typejournalArticleen


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