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Phytogenic polyphenols as glycogen phosphorylase inhibitors: The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes

dc.creatorStravodimos G.A., Chetter B.A., Kyriakis E., Kantsadi A.L., Chatzileontiadou D.S.M., Skamnaki V.T., Kato A., Hayes J.M., Leonidas D.D.en
dc.date.accessioned2023-01-31T10:04:22Z
dc.date.available2023-01-31T10:04:22Z
dc.date.issued2017
dc.identifier10.2174/0929867324666161118122534
dc.identifier.issn09298673
dc.identifier.urihttp://hdl.handle.net/11615/79502
dc.description.abstractGlycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors. © 2017 Bentham Science Publishers.en
dc.language.isoenen
dc.sourceCurrent Medicinal Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016162210&doi=10.2174%2f0929867324666161118122534&partnerID=40&md5=5ec56509084edd33d38b3e9095549a6a
dc.subjectalpha glucosidase inhibitoren
dc.subjectantidiabetic agenten
dc.subjectantioxidanten
dc.subjectflavonoiden
dc.subjectglycogen phosphorylaseen
dc.subjectglycosyltransferase inhibitoren
dc.subjectpolyphenol derivativeen
dc.subjectquercetinen
dc.subjectterpenoid derivativeen
dc.subjecttriterpene derivativeen
dc.subjectenzyme inhibitoren
dc.subjectglucose blood levelen
dc.subjectglycogen phosphorylaseen
dc.subjectpolyphenolen
dc.subjecttriterpeneen
dc.subjectallosterismen
dc.subjectantidiabetic activityen
dc.subjectantioxidant activityen
dc.subjectbinding affinityen
dc.subjectdrug binding siteen
dc.subjectdrug conformationen
dc.subjectdrug designen
dc.subjectdrug effecten
dc.subjectdrug potencyen
dc.subjectdrug structureen
dc.subjectglycemic controlen
dc.subjecthumanen
dc.subjectligand bindingen
dc.subjectnon insulin dependent diabetes mellitusen
dc.subjectnonhumanen
dc.subjectprotein interactionen
dc.subjectprotein ligand interactionen
dc.subjectprotein structureen
dc.subjectReviewen
dc.subjectteaen
dc.subjectX ray crystallographyen
dc.subjectanimalen
dc.subjectantagonists and inhibitorsen
dc.subjectblooden
dc.subjectchemistryen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectglucose blood levelen
dc.subjectmetabolismen
dc.subjectAnimalsen
dc.subjectBlood Glucoseen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectEnzyme Inhibitorsen
dc.subjectGlycogen Phosphorylaseen
dc.subjectHumansen
dc.subjectPolyphenolsen
dc.subjectTriterpenesen
dc.subjectBentham Science Publishers B.V.en
dc.titlePhytogenic polyphenols as glycogen phosphorylase inhibitors: The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetesen
dc.typeotheren


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