Steroid-responsive neutropenia in a cat with progressive feline leukemia virus infection
Date
2020Language
en
Sujet
Résumé
An 8-month-old female domestic shorthair cat was presented to the Animal Medical Center with anorexia, lethargy, and mild gastrointestinal signs. A CBC revealed a profound neutropenia, and serologic testing with an in-house test kit (SNAP FIV/FeLV Combo, IDEXX) was positive for feline leukemia virus (FeLV) antigen. Serial hematologic examinations during hospitalization showed a persistent neutropenia with occasionally severe anemia and thrombocytopenia. Prednisolone administration afforded complete hematologic remission within 3 days. Four weeks after the premature discontinuation of prednisolone, the patient relapsed; however, complete and prolonged hematologic remission was achieved after prednisolone was re-induced. Bone marrow aspiration cytology was consistent with immune-mediated destruction of the mature myeloid cells. steroid-responsive (likely immune-mediated) cytopenias rarely occur in cats with progressive FeLV infection. Although only a few cases of FeLV-positive, severely neutropenic cats that responded to immunosuppressive therapy have been reported, this case highlights that a grave prognosis should not always be given to these FeLV-positive cats. © 2020 American Society for Veterinary Clinical Pathology
Collections
Related items
Showing items related by title, author, creator and subject.
-
A prospective epidemiological, clinical, and clinicopathologic study of feline leukemia virus and feline immunodeficiency virus infection in 435 cats from Greece
Kokkinaki K.G., Saridomichelakis M.N., Leontides L., Mylonakis M.E., Konstantinidis A.O., Steiner J.M., Suchodolski J.S., Xenoulis P.G. (2021)Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses causing significant morbidity and mortality in cats. The aim of this study was to describe the epidemiological, clinical and clinicopathologic ... -
Low prevalence of HCV, HIV, and HTLV-I/II infection markers in northwestern Greece: Results of a 3-year prospective donor study (1995-1997)
Zervou, E. K.; Boumba, D. S.; Liaskos, Ch; Georgiadou, S.; Tsianos, E. V.; Dalekos, G. N. (2003)Background: The risk of infection with transfusion-transmitted viruses has been reduced remarkably. A zero-risk blood supply, however, remains a popular goal. A 3-year prospective donor study was conducted in the Epirus ... -
Markers of hepatitis viruses and human T-lymphotropic virus types I/II in patients who have undergone open-heart surgery: Evidence of increased risk for exposure to HBV and HEV
Zervou, E. K.; Georgiadou, S. P.; Liapi, G. K.; Karabini, F.; Giogiakas, V.; Zisiadis, K.; Gatselis, N. K.; Goudevenos, I.; Dalekos, G. N. (2005)Background: Open-heart procedure is characterized by a high-risk for contracting blood-borne infections. We evaluated the prevalence of several markers of hepatitis viruses (B-E) and human T-cell lymphotropic virus types ...