dc.creator | Sobejana M., van den Hoek J., Metsios G.S., Kitas G.D., van der Leeden M., Verberne S., Jorstad H.T., Pijnappels M., Lems W.F., Nurmohamed M.T., van der Esch M. | en |
dc.date.accessioned | 2023-01-31T09:58:18Z | |
dc.date.available | 2023-01-31T09:58:18Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1007/s10067-022-06343-4 | |
dc.identifier.issn | 07703198 | |
dc.identifier.uri | http://hdl.handle.net/11615/79141 | |
dc.description.abstract | Objective: In patients with rheumatoid arthritis (RA) with cardiovascular disease risk, it is unknown whether exercises are safe, improve cardiorespiratory fitness and reduce disease-related symptoms and cardiovascular-disease (CVD) risk factors. We aimed to investigate in RA patients with CVD risk: (1) safety of medium to high-intensity aerobic exercises, (2) potential changes of cardiorespiratory fitness and (3) disease activity and CVD risk factors in response to the exercises. Methods: Single-arm pilot-exercise intervention study including 26 consecutive patients (21 women) with > 4% 10-year risk of CVD mortality according to the Dutch Systematic Coronary Risk Evaluation. Aerobic exercises consisted of two supervised-sessions and five home-sessions per week for 12 weeks. Patients were required to exercise at intensities between 65 and 85% of their maximum heart rate. To assess safety, we recorded exercise related adverse events. Before and after the exercises, cardiorespiratory fitness was assessed with a graded maximal oxygen-uptake exercise test, while disease activity was evaluated via the Disease Activity Score-28 (DAS28) using the erythrocyte segmentation rate (ESR). Resting blood pressure, ESR and total cholesterol were assessed as CVD risk factors. Results: Twenty out of 26 patients performed the 12-week exercises without any adverse events. According to patients, withdrawals were unrelated to the exercises. Exercises increased cardiorespiratory fitness (pre: 15.91 vs. post: 18.15 ml.kg−1 min−1, p = 0.003) and decreased DAS28 (pre: 2.86 vs. post: 2.47, p = 0.04). No changes were detected in CVD risk factors. Conclusion: A 12-week exercise intervention seems to be safe and improves cardiorespiratory fitness and disease activity in patients with RA with a high risk for cardiovascular diseases.Key Points1. Rheumatoid arthritis patients with high cardiovascular disease risk were able to perform a maximum exercise test and a 12-week aerobic-based medium-to-high intensity exercise intervention.2. The exercise intervention improved cardiorespiratory fitness and disease activity in rheumatoid arthritis patients with high cardiovascular disease risk.3. Cardiorespiratory fitness levels were still low post-exercise intervention (i.e. 18.15 ml.kg−1min−1 compared to the 20.9 ml.kg−1min−1 baseline mean of the RA patients without CVD risk). © 2022, The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR). | en |
dc.language.iso | en | en |
dc.source | Clinical Rheumatology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137241510&doi=10.1007%2fs10067-022-06343-4&partnerID=40&md5=314b4e184cc553e037004363c532e2bf | |
dc.subject | analgesic agent | en |
dc.subject | antihypertensive agent | en |
dc.subject | beta adrenergic receptor blocking agent | en |
dc.subject | C reactive protein | en |
dc.subject | disease modifying antirheumatic drug | en |
dc.subject | folic acid | en |
dc.subject | high density lipoprotein cholesterol | en |
dc.subject | hypocholesterolemic agent | en |
dc.subject | methotrexate | en |
dc.subject | nonsteroid antiinflammatory agent | en |
dc.subject | prednisolone | en |
dc.subject | triacylglycerol | en |
dc.subject | tumor necrosis factor inhibitor | en |
dc.subject | adult | en |
dc.subject | aerobic exercise | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | blood pressure | en |
dc.subject | cardiorespiratory fitness | en |
dc.subject | cardiovascular disease | en |
dc.subject | cardiovascular mortality | en |
dc.subject | cardiovascular risk | en |
dc.subject | cardiovascular risk factor | en |
dc.subject | cholesterol blood level | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | DAS28 | en |
dc.subject | disease activity | en |
dc.subject | disease duration | en |
dc.subject | disease severity | en |
dc.subject | erythrocyte sedimentation rate | en |
dc.subject | exercise intensity | en |
dc.subject | exercise test | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | functional training | en |
dc.subject | home care | en |
dc.subject | human | en |
dc.subject | inflammation | en |
dc.subject | interval training | en |
dc.subject | kinesiotherapy | en |
dc.subject | knee osteoarthritis | en |
dc.subject | low back pain | en |
dc.subject | male | en |
dc.subject | maximal oxygen uptake | en |
dc.subject | numeric rating scale | en |
dc.subject | patient safety | en |
dc.subject | pilot study | en |
dc.subject | resistance training | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | systolic blood pressure | en |
dc.subject | cardiovascular disease | en |
dc.subject | complication | en |
dc.subject | kinesiotherapy | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | Arthritis, Rheumatoid | en |
dc.subject | Cardiorespiratory Fitness | en |
dc.subject | Cardiovascular Diseases | en |
dc.subject | Exercise Therapy | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Pilot Projects | en |
dc.subject | Springer Science and Business Media Deutschland GmbH | en |
dc.title | Exercise intervention on cardiorespiratory fitness in rheumatoid arthritis patients with high cardiovascular disease risk: a single-arm pilot study | en |
dc.type | journalArticle | en |