dc.creator | Samara S., Vemmou A., Kyrkou A., Papamichael C., Korompoki E., Ntaios G., Manios E., Stamatelopoulos K., Protogerou A.D., Vemmos K. | en |
dc.date.accessioned | 2023-01-31T09:53:35Z | |
dc.date.available | 2023-01-31T09:53:35Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1097/HJH.0000000000003244 | |
dc.identifier.issn | 02636352 | |
dc.identifier.uri | http://hdl.handle.net/11615/78753 | |
dc.description.abstract | Background and purpose: Stroke patients' management might be improved by addressing the role of aortic stiffness (carotid-femoral pulse wave velocity: cfPWV) and pressure wave reflections (PWRs, augmentation index: AIx) in their pathogenesis and outcome. We tested the hypothesis that cfPWV and AIx, separately and combined, predict long-term outcomes [all-cause mortality, incidence of cardiovascular events, stroke recurrence and disability defined by modified Ranking Scale (mRS) ≥3] in patients with acute stroke, using data from the 'Athens Stroke Registry'. Methods: Data from 552 patients (70% men, age: 66.1 ∓10.4years, 13.4% deaths from any cause, 21.2% cardiovascular events, 14.1% stroke recurrences and 20.1% poor mRS, mean follow-up 68.4∓41.4months) were analyzed. Results: The main findings were that: high aortic stiffness (cfPWV > 13 m/s) alone is an independent predictor of all-cause mortality and cardiovascular (CV) events, but not of stroke recurrence and poor functional outcome; evaluated separately from aortic stiffness, neither low nor high PWRs have any prognostic value; even after multiple adjustments, patients with both high aortic stiffness (cfPWV > 13 m/s) and low PWRs (Aix < 22%) have almost two-fold higher hazard ratio, not only for all-cause mortality and CV events but also for stroke recurrence and poor functional outcome. Conclusions: The present study provides evidence about the role of aortic stiffness, PWRs and their combined incremental value in the long-term survival, morbidity, and functional disability after acute stroke. © 2022 Wolters Kluwer Health, Inc. | en |
dc.language.iso | en | en |
dc.source | Journal of Hypertension | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139309012&doi=10.1097%2fHJH.0000000000003244&partnerID=40&md5=f88681b0482c4ebebfad3b76fbb82d68 | |
dc.subject | acetylsalicylic acid | en |
dc.subject | antithrombocytic agent | en |
dc.subject | beta adrenergic receptor blocking agent | en |
dc.subject | calcium channel blocking agent | en |
dc.subject | creatinine | en |
dc.subject | dipeptidyl carboxypeptidase inhibitor | en |
dc.subject | diuretic agent | en |
dc.subject | fibrinolytic agent | en |
dc.subject | hydroxymethylglutaryl coenzyme A reductase inhibitor | en |
dc.subject | warfarin | en |
dc.subject | adolescent | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | all cause mortality | en |
dc.subject | arterial pressure | en |
dc.subject | arterial stiffness | en |
dc.subject | Article | en |
dc.subject | augmentation index | en |
dc.subject | cardiovascular disease | en |
dc.subject | carotid-femoral pulse wave velocity | en |
dc.subject | cerebrovascular accident | en |
dc.subject | clinical outcome | en |
dc.subject | cohort analysis | en |
dc.subject | controlled study | en |
dc.subject | diabetes mellitus | en |
dc.subject | disability | en |
dc.subject | dyslipidemia | en |
dc.subject | female | en |
dc.subject | fibrinolytic therapy | en |
dc.subject | follow up | en |
dc.subject | functional status | en |
dc.subject | hematocrit | en |
dc.subject | hospital discharge | en |
dc.subject | human | en |
dc.subject | hypertension | en |
dc.subject | hypothesis | en |
dc.subject | incidence | en |
dc.subject | ischemic heart disease | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | National Institutes of Health Stroke Scale | en |
dc.subject | prediction | en |
dc.subject | predictive value | en |
dc.subject | pressure wave reflection | en |
dc.subject | pulse wave | en |
dc.subject | Rankin scale | en |
dc.subject | recurrent disease | en |
dc.subject | retrospective study | en |
dc.subject | secondary prevention | en |
dc.subject | transient ischemic attack | en |
dc.subject | blood pressure | en |
dc.subject | carotid artery | en |
dc.subject | cerebrovascular accident | en |
dc.subject | middle aged | en |
dc.subject | pulse wave | en |
dc.subject | register | en |
dc.subject | Aged | en |
dc.subject | Blood Pressure | en |
dc.subject | Carotid Arteries | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Pulse Wave Analysis | en |
dc.subject | Registries | en |
dc.subject | Stroke | en |
dc.subject | Vascular Stiffness | en |
dc.subject | Lippincott Williams and Wilkins | en |
dc.title | Prediction of long-term outcomes by arterial stiffness and pressure wave reflections in patients with acute stroke: the Athens Stroke Registry | en |
dc.type | journalArticle | en |