Association of IL-10 gene promoter polymorphisms with food allergy susceptibility and serum IL-10 level in a pediatric Caucasian population
dc.creator | Nedelkopoulou N., Taparkou A., Raftopoulou S., Gidaris D., Xinias I., Mavroudi A., Dhawan A., Farmaki E. | en |
dc.date.accessioned | 2023-01-31T09:40:05Z | |
dc.date.available | 2023-01-31T09:40:05Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1111/pai.13407 | |
dc.identifier.issn | 09056157 | |
dc.identifier.uri | http://hdl.handle.net/11615/77131 | |
dc.description.abstract | Background: Interleukin 10 has been shown to play a critical role in the regulation of the immune responses in allergic diseases. Aim: To investigate if genetic polymorphisms in the promoter region of the IL-10 gene are associated with food allergy (FA) susceptibility in Caucasian pediatric patients with concomitant allergic diseases and IL-10 levels. Methods: The single nucleotide polymorphisms (SNPs) at -1082A > G (rs1800896), -819 T > C (rs1800871), and -592A > C (rs1800872) of 62 pediatric patients with IgE-mediated FA were analyzed and correlated with clinical parameters, serum IgE and IL-10 levels. The results were compared with those of 92 healthy controls without FA, personal and/or family history of atopy. Results: Analysis and comparison of genotype distributions, allele frequencies, and haplotypes showed that none of the genotypes confers an increased risk of FA. The genotype -1082 AA in FA patients was associated with moderate to severe symptoms of FA, the development of atopic asthma, and higher levels of IL-10. In a linear regression study, we confirmed that the genotype -1082 AA acts as an independent factor for the higher levels of IL-10. A positive association was also observed between -819T/C and -592 A/C SNPs and later onset of FA. Conclusion: Polymorphisms in the promoter region of the IL-10 gene are not associated with FA susceptibility in our cohort. In FA patients, -1082 A/G SNPs seem to influence the production of IL-10, the severity of FA symptoms, and the development of atopic asthma in this population. © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. | en |
dc.language.iso | en | en |
dc.source | Pediatric Allergy and Immunology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097873764&doi=10.1111%2fpai.13407&partnerID=40&md5=dfcc33ecc2a9d6d202b034162d03c97c | |
dc.subject | immunoglobulin E | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 10 | en |
dc.subject | allergic asthma | en |
dc.subject | Article | en |
dc.subject | atopy | en |
dc.subject | Caucasian | en |
dc.subject | child | en |
dc.subject | clinical study | en |
dc.subject | controlled study | en |
dc.subject | demography | en |
dc.subject | diarrhea | en |
dc.subject | disease predisposition | en |
dc.subject | erythema | en |
dc.subject | face edema | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | food allergy | en |
dc.subject | gene frequency | en |
dc.subject | genetic association | en |
dc.subject | genotype | en |
dc.subject | haplotype | en |
dc.subject | homozygosity | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | pediatric patient | en |
dc.subject | priority journal | en |
dc.subject | promoter region | en |
dc.subject | protein blood level | en |
dc.subject | risk | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | vomiting | en |
dc.subject | case control study | en |
dc.subject | food allergy | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | promoter region | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | Case-Control Studies | en |
dc.subject | Child | en |
dc.subject | Food Hypersensitivity | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Interleukin-10 | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Promoter Regions, Genetic | en |
dc.subject | Blackwell Publishing Ltd | en |
dc.title | Association of IL-10 gene promoter polymorphisms with food allergy susceptibility and serum IL-10 level in a pediatric Caucasian population | en |
dc.type | journalArticle | en |
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