dc.creator | Nagraj S., Varrias D., Hernandez Romero G., Santos H.T., Karamanis D., Sagris D., Korompoki E., Milionis H., Palaiodimos L., Ntaios G. | en |
dc.date.accessioned | 2023-01-31T09:03:00Z | |
dc.date.available | 2023-01-31T09:03:00Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1161/STROKEAHA.122.040233 | |
dc.identifier.issn | 00392499 | |
dc.identifier.uri | http://hdl.handle.net/11615/76873 | |
dc.description.abstract | Background: COVID-19 has been frequently associated with an increased risk of thrombotic complications. There have also been reports of an increased likelihood of stroke, although its true incidence in patients with COVID-19 is currently unknown. Methods: Electronic databases PubMed and Scopus were searched from inception up to July 30, 2021 to identify randomized controlled studies in patients with confirmed COVID-19 undergoing one or more interventions. Studies were screened for eligibility using a predefined inclusion criterion and selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A random-effects model meta-analysis was conducted, and heterogeneity was assessed using I-squared test. Results: Out of 3960 potentially eligible articles, 77 randomized studies (38 732 patients) were included. Mean age of the study population was 55±9.3 years. Females constituted 38% of the study population and mean duration of follow-up after study enrollment was 23±12.9 days. Cumulative incidence of stroke in the overall study population was 0.001 (95% CI, 0.001-0.002) with a total of 65 events in 38 732 patients, corresponding to an absolute incidence of 0.168%. Incidence of stroke in the inpatient population was 0.001 (95% CI, 0.001-0.002; 65 events in 37 069 patients), corresponding to an absolute incidence of 0.175%. No strokes were observed in the outpatient setting. Conclusions: The overall incidence of stroke in patients with COVID-19 appears to be lower than that reported in previous observational reports. © 2022 Lippincott Williams and Wilkins. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Stroke | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140658947&doi=10.1161%2fSTROKEAHA.122.040233&partnerID=40&md5=e6c6e0ff4997b3877233aebda268b44a | |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cerebrovascular accident | en |
dc.subject | consensus development | en |
dc.subject | controlled study | en |
dc.subject | coronavirus disease 2019 | en |
dc.subject | cumulative incidence | en |
dc.subject | female | en |
dc.subject | genetic heterogeneity | en |
dc.subject | hospital patient | en |
dc.subject | human | en |
dc.subject | intensive care unit | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | outpatient | en |
dc.subject | pandemic | en |
dc.subject | randomized controlled trial (topic) | en |
dc.subject | sensitivity analysis | en |
dc.subject | systematic review | en |
dc.subject | cerebrovascular accident | en |
dc.subject | incidence | en |
dc.subject | meta analysis | en |
dc.subject | COVID-19 | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Incidence | en |
dc.subject | Middle Aged | en |
dc.subject | Randomized Controlled Trials as Topic | en |
dc.subject | Stroke | en |
dc.subject | Wolters Kluwer Health | en |
dc.title | Incidence of Stroke in Randomized Trials of COVID-19 Therapeutics: A Systematic Review and Meta-Analysis | en |
dc.type | journalArticle | en |