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Anti-platelet effects of vitamin supplements in age-related macular degeneration: an in vitro study

dc.creatorMoschos M.M., Laios K., Androudi S., Ladas D.S., Chatziralli I.P.en
dc.date.accessioned2023-01-31T09:01:30Z
dc.date.available2023-01-31T09:01:30Z
dc.date.issued2018
dc.identifier10.1080/15569527.2017.1409754
dc.identifier.issn15569527
dc.identifier.urihttp://hdl.handle.net/11615/76761
dc.description.abstractObjective: The purpose of this experimental study was to investigate the role of vitamin supplements (Ocuvite, Vitalux Omega, and Nutrof Total) as possible inhibitors of the onset of age-related macular degeneration (AMD). Materials and methods: The anti-aggregating effect of each vitamin was determined against four accumulative factors namely, platelet activating factor (PAF), adenosine diphosphate (ADP), thrombin receptor-activating peptide (TRAP), and arachidonic acid (AA) in the platelet rich plasma (PRP) of healthy volunteers. Results: Ocuvite, Vitalux Omega, and Nutrof Total were more potent inhibitors against PAF and ADP compared to TRAP and AA. Among the three vitamins, Nutrof Total displayed more potent inhibitions against TRAP and AA, while against PAF and ADP all the three vitamins revealed similar IC50 values. Conclusions: The vitamins Ocuvite, Vitalux Omega, and Nutrof Total have anti-aggregating effects and therefore can be used against AMD in healthy volunteers. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.en
dc.language.isoenen
dc.sourceCutaneous and Ocular Toxicologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85038030953&doi=10.1080%2f15569527.2017.1409754&partnerID=40&md5=2caea4748f56f6d95cdf0bba75c00e09
dc.subjectadenosine diphosphateen
dc.subjectalpha tocopherolen
dc.subjectarachidonic aciden
dc.subjectascorbic aciden
dc.subjectcopperen
dc.subjectdocosahexaenoic aciden
dc.subjectglutathioneen
dc.subjecthydrocarbonen
dc.subjecticosapentaenoic aciden
dc.subjectlipiden
dc.subjectnutrof totalen
dc.subjectocuviteen
dc.subjectomega 3 fatty aciden
dc.subjectproteinen
dc.subjectresveratrolen
dc.subjectseleniumen
dc.subjectthrombin receptor activating peptideen
dc.subjectthrombocyte activating factoren
dc.subjectvitalux omegaen
dc.subjectvitaminen
dc.subjectxanthophyllen
dc.subjectzeaxanthinen
dc.subjectzincen
dc.subjectthrombin receptoren
dc.subjectvitaminen
dc.subjectage related macular degenerationen
dc.subjectanticoagulationen
dc.subjectArticleen
dc.subjectdrug potencyen
dc.subjectexperimental studyen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectIC50en
dc.subjectin vitro studyen
dc.subjectthrombocyte aggregationen
dc.subjectthrombocyte rich plasmaen
dc.subjectvitamin supplementationen
dc.subjectantagonists and inhibitorsen
dc.subjectcomparative studyen
dc.subjectdietary supplementen
dc.subjectdrug effecten
dc.subjectmacular degenerationen
dc.subjectmetabolismen
dc.subjectnormal humanen
dc.subjectphysiologyen
dc.subjectthrombocyteen
dc.subjectAdenosine Diphosphateen
dc.subjectArachidonic Aciden
dc.subjectBlood Plateletsen
dc.subjectDietary Supplementsen
dc.subjectHealthy Volunteersen
dc.subjectHumansen
dc.subjectInhibitory Concentration 50en
dc.subjectMacular Degenerationen
dc.subjectPlatelet Activating Factoren
dc.subjectPlatelet Aggregationen
dc.subjectReceptors, Thrombinen
dc.subjectVitaminsen
dc.subjectTaylor and Francis Ltden
dc.titleAnti-platelet effects of vitamin supplements in age-related macular degeneration: an in vitro studyen
dc.typejournalArticleen


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