dc.creator | Milionis H., Ntaios G., Papavasileiou V., Spengos K., Manios E., Elisaf M., Vemmos K. | en |
dc.date.accessioned | 2023-01-31T09:00:07Z | |
dc.date.available | 2023-01-31T09:00:07Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1016/j.jstrokecerebrovasdis.2017.06.052 | |
dc.identifier.issn | 10523057 | |
dc.identifier.uri | http://hdl.handle.net/11615/76639 | |
dc.description.abstract | Background and objective Diabetes mellitus is associated with an increased risk of stroke and poor outcome following a stroke event. We assessed the impact of discharge treatment with aspirin versus clopidogrel on the 10-year survival of patients with type 2 diabetes after a first-ever noncardioembolic acute ischemic stroke (AIS). Methods This was a post hoc analysis of the Athens Stroke Outcome Project. Study outcomes included death, stroke recurrence, and a composite cardiovascular disease (CVD) end point (recurrent stroke, myocardial infarction, unstable angina, coronary revascularization, aortic aneurysm rupture, or sudden death). Kaplan–Meier survival curve and Cox regression analyses were performed. Results A total of 304 (93 women) diabetic patients receiving either aspirin (n = 197) or clopidogrel (n = 107) were studied. The 10-year survival was better in clopidogrel-treated patients than in aspirin-treated patients (19 deaths [17.7%] for clopidogrel versus 55 deaths [27.9%] for aspirin; log-rank test: 4.91, P =.027). Similarly, clopidogrel was associated with a favorable impact on recurrent stroke (12 events [11.2%] for clopidogrel versus 39 events [19.7%] for aspirin; log-rank test: 4.46, P =.035) and on the composite CVD end point (21 events [19.6%] for clopidogrel versus 54 events [27.4%] for aspirin; log-rank test: 4.17, P =.041). In the multivariable analysis, the beneficial effect of clopidogrel over aspirin on both primary and secondary end points was independent of age, gender, the presence of CVD or CVD risk factors, and stroke severity. Conclusions Our findings indicate a favorable effect of clopidogrel at discharge compared with aspirin in preventing death, recurrent stroke, and CVD events in diabetic patients with a first-ever noncardioembolic AIS. © 2017 National Stroke Association | en |
dc.language.iso | en | en |
dc.source | Journal of Stroke and Cerebrovascular Diseases | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026251681&doi=10.1016%2fj.jstrokecerebrovasdis.2017.06.052&partnerID=40&md5=1a51291a04c1855d01953707115d35be | |
dc.subject | acetylsalicylic acid | en |
dc.subject | clopidogrel | en |
dc.subject | glucose | en |
dc.subject | glycosylated hemoglobin | en |
dc.subject | insulin | en |
dc.subject | oral antidiabetic agent | en |
dc.subject | warfarin | en |
dc.subject | acetylsalicylic acid | en |
dc.subject | antithrombocytic agent | en |
dc.subject | clopidogrel | en |
dc.subject | ticlopidine | en |
dc.subject | aged | en |
dc.subject | anticoagulant therapy | en |
dc.subject | aortic rupture | en |
dc.subject | Article | en |
dc.subject | atrial fibrillation | en |
dc.subject | bleeding | en |
dc.subject | brain ischemia | en |
dc.subject | cardiovascular disease | en |
dc.subject | cardiovascular risk | en |
dc.subject | clinical evaluation | en |
dc.subject | clinical outcome | en |
dc.subject | controlled study | en |
dc.subject | death | en |
dc.subject | diabetic patient | en |
dc.subject | diet restriction | en |
dc.subject | disease duration | en |
dc.subject | disease severity | en |
dc.subject | drug effect | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | glucose blood level | en |
dc.subject | heart muscle revascularization | en |
dc.subject | hospital discharge | en |
dc.subject | human | en |
dc.subject | infection | en |
dc.subject | loading drug dose | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | medical history | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | post hoc analysis | en |
dc.subject | prevalence | en |
dc.subject | priority journal | en |
dc.subject | recurrent disease | en |
dc.subject | sudden death | en |
dc.subject | survival time | en |
dc.subject | valvular heart disease | en |
dc.subject | analogs and derivatives | en |
dc.subject | blood | en |
dc.subject | brain ischemia | en |
dc.subject | cerebrovascular accident | en |
dc.subject | chi square distribution | en |
dc.subject | comparative study | en |
dc.subject | epidemiology | en |
dc.subject | Greece | en |
dc.subject | Kaplan Meier method | en |
dc.subject | middle aged | en |
dc.subject | mortality | en |
dc.subject | multivariate analysis | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | odds ratio | en |
dc.subject | procedures | en |
dc.subject | proportional hazards model | en |
dc.subject | protection | en |
dc.subject | retrospective study | en |
dc.subject | risk factor | en |
dc.subject | secondary prevention | en |
dc.subject | time factor | en |
dc.subject | treatment outcome | en |
dc.subject | very elderly | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Aspirin | en |
dc.subject | Brain Ischemia | en |
dc.subject | Chi-Square Distribution | en |
dc.subject | Diabetes Mellitus, Type 2 | en |
dc.subject | Female | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Kaplan-Meier Estimate | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Multivariate Analysis | en |
dc.subject | Odds Ratio | en |
dc.subject | Patient Discharge | en |
dc.subject | Platelet Aggregation Inhibitors | en |
dc.subject | Proportional Hazards Models | en |
dc.subject | Protective Factors | en |
dc.subject | Recurrence | en |
dc.subject | Retrospective Studies | en |
dc.subject | Risk Factors | en |
dc.subject | Secondary Prevention | en |
dc.subject | Stroke | en |
dc.subject | Ticlopidine | en |
dc.subject | Time Factors | en |
dc.subject | Treatment Outcome | en |
dc.subject | W.B. Saunders | en |
dc.title | Aspirin Versus Clopidogrel for Type 2 Diabetic Patients with First-Ever Noncardioembolic Acute Ischemic Stroke: Ten-Year Survival Data from the Athens Stroke Outcome Project | en |
dc.type | journalArticle | en |