dc.creator | Malli F., Papakosta D., Antoniou K., Dimadi M., Polychronopoulos V., Malagari K., Oikonomou A., Bouros D.E., Daniil Z. | en |
dc.date.accessioned | 2023-01-31T08:56:24Z | |
dc.date.available | 2023-01-31T08:56:24Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1183/23120541.00014-2018 | |
dc.identifier.issn | 23120541 | |
dc.identifier.uri | http://hdl.handle.net/11615/76212 | |
dc.description.abstract | Background: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival. Methods: This retrospective study included 97 patients with CPFE. Demographic and clinical data, pulmonary function tests, echocardiography results and bronchoalveolar lavage analysis were recorded. Results: Most patients were male (94.8%) and 92% were current or ex-smokers. Spirometry results were abnormal (forced vital capacity (FVC) 72.9±19.9% pred and forced expiratory volume in 1 s/FVC 82.9±9.7%) with reduced diffusing capacity of the lung for carbon monoxide (DLCO) (42.3±17.4% pred). Mean systolic pulmonary arterial pressure was 41.9±19.7 mmHg and pulmonary hypertension was present in 58.8% of patients. Mean 6-min walk distance was 335.4±159.4 m. Mean emphysema score was 14.23±8.69% and mean interstitial lung disease (ILD) extent was 39.58±19.82%. Mean survival was 84 months (95% CI 72-96 months). Patients with DLCO ≥39% pred had better survival than patients with DLCO <39% pred (p=0.031). Patients with ILD extent ≥30% had worse survival than patients with ILD extent <30% (p=0.037). Conclusions: Our results indicate that CPFE patients have preserved lung volumes associated with disproportionately reduced DLCO, while reduced DLCO and increased ILD extent was associated with worse prognosis. © ERS 2019. | en |
dc.language.iso | en | en |
dc.source | ERJ Open Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081967272&doi=10.1183%2f23120541.00014-2018&partnerID=40&md5=06a16a5b8fd14d7f79c4b53235e7f751 | |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cohort analysis | en |
dc.subject | disease severity | en |
dc.subject | Doppler echocardiography | en |
dc.subject | emphysema | en |
dc.subject | female | en |
dc.subject | forced expiratory volume | en |
dc.subject | forced vital capacity | en |
dc.subject | human | en |
dc.subject | lung fibrosis | en |
dc.subject | lung function test | en |
dc.subject | lung lavage | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | mortality | en |
dc.subject | multicenter study | en |
dc.subject | overall survival | en |
dc.subject | pulmonary hypertension | en |
dc.subject | retrospective study | en |
dc.subject | six minute walk test | en |
dc.subject | spirometry | en |
dc.subject | systolic blood pressure | en |
dc.subject | European Respiratory Society | en |
dc.title | Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort | en |
dc.type | journalArticle | en |