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Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

dc.creatorLe Reste P.J., Pineau R., Voutetakis K., Samal J., Jégou G., Lhomond S., Gorman A.M., Samali A., Patterson J.B., Zeng Q., Pandit A., Aubry M., Soriano N., Etcheverry A., Chatziioannou A., Mosser J., Avril T., Chevet E.en
dc.date.accessioned2023-01-31T08:49:20Z
dc.date.available2023-01-31T08:49:20Z
dc.date.issued2020
dc.identifier10.1016/j.canlet.2020.08.028
dc.identifier.issn03043835
dc.identifier.urihttp://hdl.handle.net/11615/75730
dc.description.abstractGlioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed an immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy. © 2020 Elsevier B.V.en
dc.language.isoenen
dc.sourceCancer Lettersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85090271230&doi=10.1016%2fj.canlet.2020.08.028&partnerID=40&md5=87f2330f4d8cf8f4cfae844819e98dde
dc.subjectmkc 8866en
dc.subjectprotein IRE1en
dc.subjectribonuclease inhibitoren
dc.subjecttemozolomideen
dc.subjectunclassified drugen
dc.subjectbenzopyran derivativeen
dc.subjectMKC8866en
dc.subjectmorpholine derivativeen
dc.subjectanimal cellen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectanimal tissueen
dc.subjectArticleen
dc.subjectcancer chemotherapyen
dc.subjectcancer radiotherapyen
dc.subjectclinical protocolen
dc.subjectcontrolled studyen
dc.subjectdrug efficacyen
dc.subjectdrug sensitizationen
dc.subjectglioblastomaen
dc.subjectimmunohistochemistryen
dc.subjectin vitro studyen
dc.subjectin vivo studyen
dc.subjectmaleen
dc.subjectmouseen
dc.subjectmouse modelen
dc.subjectnonhumanen
dc.subjectpreclinical studyen
dc.subjectpriority journalen
dc.subjectStupp protocolen
dc.subjectanimalen
dc.subjectbrain tumoren
dc.subjectcraniotomyen
dc.subjectdrug effecten
dc.subjectdrug screeningen
dc.subjectdrug therapyen
dc.subjectgene expression profilingen
dc.subjectgene expression regulationen
dc.subjectgeneticsen
dc.subjectglioblastomaen
dc.subjecthumanen
dc.subjectimmunocompetenceen
dc.subjectimmunologyen
dc.subjectintralesional drug administrationen
dc.subjectmultimodality cancer therapyen
dc.subjectneoadjuvant therapyen
dc.subjectproceduresen
dc.subjectradiotherapyen
dc.subjecttreatment outcomeen
dc.subjecttumor cell lineen
dc.subjecttumor microenvironmenten
dc.subjectAnimalsen
dc.subjectBenzopyransen
dc.subjectBrain Neoplasmsen
dc.subjectCell Line, Tumoren
dc.subjectCombined Modality Therapyen
dc.subjectCraniotomyen
dc.subjectDrug Therapyen
dc.subjectGene Expression Profilingen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectGlioblastomaen
dc.subjectHumansen
dc.subjectImmunocompetenceen
dc.subjectInjections, Intralesionalen
dc.subjectMiceen
dc.subjectMorpholinesen
dc.subjectNeoadjuvant Therapyen
dc.subjectRadiotherapyen
dc.subjectTreatment Outcomeen
dc.subjectTumor Microenvironmenten
dc.subjectXenograft Model Antitumor Assaysen
dc.subjectElsevier Ireland Ltden
dc.titleLocal intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivoen
dc.typejournalArticleen


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