MicroRNAs and the Diagnosis of Childhood Acute Lymphoblastic Leukemia: Systematic Review, Meta-Analysis and Re-Analysis with Novel Small RNA-Seq Tools
dc.creator | Kyriakidis I., Kyriakidis K., Tsezou A. | en |
dc.date.accessioned | 2023-01-31T08:47:36Z | |
dc.date.available | 2023-01-31T08:47:36Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.3390/cancers14163976 | |
dc.identifier.issn | 20726694 | |
dc.identifier.uri | http://hdl.handle.net/11615/75565 | |
dc.description.abstract | MicroRNAs (miRNAs) have been implicated in childhood acute lymphoblastic leukemia (ALL) pathogenesis. We performed a systematic review and meta-analysis of miRNA single-nucleotide polymorphisms (SNPs) in childhood ALL compared with healthy children, which revealed (i) that the CC genotype of rs4938723 in pri-miR-34b/c and the TT genotype of rs543412 in miR-100 confer protection against ALL occurrence in children; (ii) no significant association between rs2910164 genotypes in miR-146a and childhood ALL; and (iii) SNPs in DROSHA, miR-449b, miR-938, miR-3117 and miR-3689d-2 genes seem to be associated with susceptibility to B-ALL in childhood. A review of published literature on differential expression of miRNAs in children with ALL compared with controls revealed a significant upregulation of the miR-128 family, miR-130b, miR-155, miR-181 family, miR-210, miR-222, miR-363 and miR-708, along with significant downregulation of miR-143 and miR-148a, seem to have a definite role in childhood ALL development. MicroRNA signatures among childhood ALL subtypes, along with differential miRNA expression patterns between B-ALL and T-ALL cases, were scrutinized. With respect to T-ALL pediatric cases, we reanalyzed RNA-seq datasets with a robust and sensitive pipeline and confirmed the significant differential expression of hsa-miR-16-5p, hsa-miR-19b-3p, hsa-miR-92a-2-5p, hsa-miR-128-3p (ranked first), hsa-miR-130b-3p and -5p, hsa-miR-181a-5p, -2-3p and -3p, hsa-miR-181b-5p and -3p, hsa-miR-145-5p and hsa-miR-574-3p, as described in the literature, along with novel identified miRNAs. © 2022 by the authors. | en |
dc.language.iso | en | en |
dc.source | Cancers | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137362849&doi=10.3390%2fcancers14163976&partnerID=40&md5=bdd3bdae274cbaf4f787076c84fdc2b5 | |
dc.subject | biological marker | en |
dc.subject | hsa miR 128 3p | en |
dc.subject | hsa miR 130b 3p | en |
dc.subject | hsa miR 130b 5p | en |
dc.subject | hsa miR 145 5p | en |
dc.subject | hsa miR 16 5p | en |
dc.subject | hsa miR 181a 2 3p | en |
dc.subject | hsa miR 181a 3p | en |
dc.subject | hsa miR 181a 5p | en |
dc.subject | hsa miR 181b 3p | en |
dc.subject | hsa miR 181b 5p | en |
dc.subject | hsa miR 19b 3p | en |
dc.subject | hsa miR 574 3p | en |
dc.subject | hsa miR 92a 2 5p | en |
dc.subject | microRNA | en |
dc.subject | microRNA 100 | en |
dc.subject | microRNA 125b | en |
dc.subject | microRNA 143 | en |
dc.subject | microRNA 146a | en |
dc.subject | microRNA 155 | en |
dc.subject | microRNA 210 | en |
dc.subject | microRNA 222 | en |
dc.subject | microRNA 223 | en |
dc.subject | miR 128 | en |
dc.subject | miR 130b | en |
dc.subject | miR 142 | en |
dc.subject | miR 148a | en |
dc.subject | miR 181 | en |
dc.subject | miR 196b | en |
dc.subject | miR 3117 | en |
dc.subject | miR 34b | en |
dc.subject | miR 34c | en |
dc.subject | miR 363 | en |
dc.subject | miR 3689d 2 | en |
dc.subject | miR 449b | en |
dc.subject | miR 708 | en |
dc.subject | miR 938 | en |
dc.subject | unclassified drug | en |
dc.subject | untranslated RNA | en |
dc.subject | acute lymphoblastic leukemia | en |
dc.subject | cancer diagnosis | en |
dc.subject | cancer susceptibility | en |
dc.subject | childhood cancer | en |
dc.subject | differential expression analysis | en |
dc.subject | down regulation | en |
dc.subject | gene expression | en |
dc.subject | genotype | en |
dc.subject | human | en |
dc.subject | meta analysis | en |
dc.subject | Review | en |
dc.subject | RNA sequencing | en |
dc.subject | sequence analysis | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | systematic review | en |
dc.subject | upregulation | en |
dc.subject | MDPI | en |
dc.title | MicroRNAs and the Diagnosis of Childhood Acute Lymphoblastic Leukemia: Systematic Review, Meta-Analysis and Re-Analysis with Novel Small RNA-Seq Tools | en |
dc.type | other | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |