Όλο το DSpace

Εμφάνιση απλής εγγραφής

Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review

dc.creatorKyrgias G., Hajiioannou J., Tolia M., Kouloulias V., Lachanas V., Skoulakis C., Skarlatos I., Rapidis A., Bizakis I.en
dc.date.accessioned2023-01-31T08:47:34Z
dc.date.available2023-01-31T08:47:34Z
dc.date.issued2016
dc.identifier10.1097/MD.0000000000005035
dc.identifier.issn00257974
dc.identifier.urihttp://hdl.handle.net/11615/75563
dc.description.abstractBackground: Multimodality therapy constitutes the standard treatment of advanced and recurrent head and neck cancer. Since locoregional recurrence comprises a major obstacle in attaining cure, the role of intraoperative radiation therapy (IORT) as an add-on in improving survival and local control of the disease has been investigated. IORT allows delivery of a single tumoricidal dose of radiation to areas of potential residual microscopic disease while minimizing doses to normal tissues. Advantages of IORT include the conformal delivery of a large dose of radiation in an exposed and precisely defined tumor bed, minimizing the risk of a geographic miss creating the potential for subsequent dose reduction of external beam radiation therapy (EBRT). This strategy allows for shortening overall treatment time and dose escalation. The aim of this review is to summarize recent published work on the use of IORT as an adjuvant modality to treat common head and neck cancer in the primary or recurrent setting. Methods: We searched the Medline, Scopus, Ovid, Cochrane, Embase, and ISI Web of Science databases for articles published from 1980 up to March 2016. Results: Based on relevant publications it appears that including IORT in the multimodal treatment may contribute to improved local control. However, the benefit in overall survival is not so clear. Conclusion: IORT seems to be a safe, promising adjunct in the management of head and neck cancer and yet further well organized clinical trials are required to determine its role more precisely. Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.en
dc.language.isoenen
dc.sourceMedicine (United States)en
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85007490339&doi=10.1097%2fMD.0000000000005035&partnerID=40&md5=f125297d5b3cac2c226a15851289c95d
dc.subjectabscessen
dc.subjectadenocarcinomaen
dc.subjectadenoid cystic carcinomaen
dc.subjectadenosquamous carcinomaen
dc.subjectadjuvant radiotherapyen
dc.subjectadvanced canceren
dc.subjectartery ruptureen
dc.subjectauditory tube dysfunctionen
dc.subjectbasal cell carcinomaen
dc.subjectbone necrosisen
dc.subjectbone painen
dc.subjectcancer controlen
dc.subjectcancer radiotherapyen
dc.subjectcancer recurrenceen
dc.subjectcancer survivalen
dc.subjectcarotid artery obstructionen
dc.subjectcarotid blowouten
dc.subjectcerebrovascular accidenten
dc.subjectClostridium difficile infectionen
dc.subjectdeep vein thrombosisen
dc.subjectdisease free survivalen
dc.subjectdistant metastasisen
dc.subjectdysphagiaen
dc.subjectepidermoid tumoren
dc.subjectexternal beam radiotherapyen
dc.subjectface painen
dc.subjectfacial nerve paralysisen
dc.subjectgastritisen
dc.subjecthead and neck canceren
dc.subjectheart muscle ischemiaen
dc.subjecthumanen
dc.subjectinfectionen
dc.subjectintraoperative radiotherapyen
dc.subjectjaw osteonecrosisen
dc.subjectlung insufficiencyen
dc.subjectmelanomaen
dc.subjectmeta analysisen
dc.subjectminimal residual diseaseen
dc.subjectmixed tumoren
dc.subjectmucosa inflammationen
dc.subjectmultimodality cancer therapyen
dc.subjectneurological complicationen
dc.subjectneuropathyen
dc.subjectoral fistulaen
dc.subjectoverall survivalen
dc.subjectpatient safetyen
dc.subjectpneumoniaen
dc.subjectpostoperative complicationen
dc.subjectprimary tumoren
dc.subjectpriority journalen
dc.subjectradiation doseen
dc.subjectradiation injuryen
dc.subjectReviewen
dc.subjectsalivary gland carcinomaen
dc.subjectsarcomaen
dc.subjectsepsisen
dc.subjectskin necrosisen
dc.subjectstress gastritisen
dc.subjectsupraglottic edemaen
dc.subjectsystematic reviewen
dc.subjecttemporomandibular joint abscessen
dc.subjecttracheovascular fistulaen
dc.subjecttrismusen
dc.subjectwound dehiscenceen
dc.subjectwound healingen
dc.subjectHead and Neck Neoplasmsen
dc.subjectmaleen
dc.subjectmortalityen
dc.subjectpathologyen
dc.subjectperoperative careen
dc.subjectproceduresen
dc.subjectprognosisen
dc.subjectradiotherapy dosageen
dc.subjectrisk assessmenten
dc.subjectsurvival analysisen
dc.subjecttreatment outcomeen
dc.subjectCombined Modality Therapyen
dc.subjectDisease-Free Survivalen
dc.subjectHead and Neck Neoplasmsen
dc.subjectHumansen
dc.subjectIntraoperative Careen
dc.subjectMaleen
dc.subjectPrognosisen
dc.subjectRadiotherapy Dosageen
dc.subjectRisk Assessmenten
dc.subjectSurvival Analysisen
dc.subjectTreatment Outcomeen
dc.subjectLippincott Williams and Wilkinsen
dc.titleIntraoperative radiation therapy (IORT) in head and neck cancer: A systematic reviewen
dc.typeotheren


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής