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Glutathione S-transferase gene polymorphism and asthma: A case-control study in a pediatric population

dc.creatorKumar A., Ahmed T., Parvez M.K., Banerjee B.D., Maqusood M., Jagirdar R.M.en
dc.date.accessioned2023-01-31T08:47:24Z
dc.date.available2023-01-31T08:47:24Z
dc.date.issued2022
dc.identifier10.2217/pgs-2022-0017
dc.identifier.issn14622416
dc.identifier.urihttp://hdl.handle.net/11615/75545
dc.description.abstractAim: To carry out a case-control study of the association of GST gene polymorphisms in pediatric asthma-related oxidative stress. Materials & methods: Asthma patients (n = 250) and age-matched healthy subjects (n = 250) DNA were genotyped for GSTM1/GSTT1 (+/+, +/-, -/+ and -/-) frequencies using multiplex-PCR and plasma oxidative stress markers (examined spectrophotometrically). Results: Asthma patients had significantly more common null-genotype GSTM1-/GSTT1- (10.4%; p = 0.002) and elevated levels of malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxyguanosine as compared with controls. In addition, the level of plasma glutathione, GST activity and ferric-reducing ability were significantly decreased as compared with controls. Conclusion: Our data revealed significant associations between GSTM1-/GSTT1- genotype and oxidative stress markers in asthmatic children, which may very likely contribute to increased incidence of bronchial asthma. © 2022 Future Medicine Ltd.en
dc.language.isoenen
dc.sourcePharmacogenomicsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85130766664&doi=10.2217%2fpgs-2022-0017&partnerID=40&md5=b979ab83d735cc761b6f30215f0603bd
dc.subject8 hydroxydeoxyguanosineen
dc.subjectbiological markeren
dc.subjectgenomic DNAen
dc.subjectglutathione transferaseen
dc.subjectglutathione transferase M1en
dc.subjectglutathione transferase T1en
dc.subjectmalonaldehydeen
dc.subjectprotein carbonylen
dc.subjectunclassified drugen
dc.subjectglutathione transferaseen
dc.subjectageen
dc.subjectArticleen
dc.subjectasthmaen
dc.subjectblood levelen
dc.subjectcase control studyen
dc.subjectchilden
dc.subjectcontrolled studyen
dc.subjectdisease associationen
dc.subjectDNA polymorphismen
dc.subjectfemaleen
dc.subjectgene frequencyen
dc.subjectgenetic associationen
dc.subjectgenotypeen
dc.subjectGST geneen
dc.subjectGSTM1 geneen
dc.subjectGSTT1 geneen
dc.subjecthumanen
dc.subjectincidenceen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmultiplex polymerase chain reactionen
dc.subjectoxidative stressen
dc.subjectpediatric patienten
dc.subjectplasmaen
dc.subjectspectrophotometryen
dc.subjectasthmaen
dc.subjectgenetic polymorphismen
dc.subjectgenetic predispositionen
dc.subjectgeneticsen
dc.subjectmetabolismen
dc.subjectrisk factoren
dc.subjectAsthmaen
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectGlutathione Transferaseen
dc.subjectHumansen
dc.subjectPolymorphism, Geneticen
dc.subjectRisk Factorsen
dc.subjectFuture Medicine Ltd.en
dc.titleGlutathione S-transferase gene polymorphism and asthma: A case-control study in a pediatric populationen
dc.typejournalArticleen


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