dc.creator | Koutalos A.A., Chalatsis G.I., Varsanis G., Malizos K.N., Karachalios T. | en |
dc.date.accessioned | 2023-01-31T08:45:53Z | |
dc.date.available | 2023-01-31T08:45:53Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1007/s00590-021-03092-z | |
dc.identifier.issn | 16338065 | |
dc.identifier.uri | http://hdl.handle.net/11615/75365 | |
dc.description.abstract | Purpose: Hip fractures are associated with functional decline and increased mortality. The aim of this study was to investigate the effect of zoledronic acid and high-dose vitamin D on function and mortality after hip fractures. Patients and methods: Forty-five patients received zoledronic acid and high dose of vitamin D during hospitalization after fracture management. These patients were compared with a control group of 46 patients. Pre- and postoperative prospectively collected data including ASA score, Charlson comorbidity score, presence of dementia, Vitamin D, and the Barthel index were available. Final follow-up was performed after one year. Primary outcome was patients’ function at final follow-up as measured with Barthel index score. Secondary outcomes included mortality, assessment of pain, and complications. Results: Barthel index score at final follow-up was decreased in both groups. There was no significant difference in Barthel index between the two groups (15.5 ± 5.0 vs 15.8 ± 5.8, p = 0.850). However, the Barthel index in the control group decreased beyond the smallest detectable change (3 points). Mortality was statistically different between groups (8.8% vs 28.2%, p = 0.047). Complications and pain at final follow-up were not different between groups. Multivariate analysis revealed that preoperative Barthel index and Charlson comorbidity score independently affected function at final follow-up. Logistic regression analysis disclosed that not receiving active treatment and complications were associated with increased mortality. Conclusions: Medical treatment after surgical management of hip fractures results in reduced mortality and lessens the functional decline associated with these fractures. © 2021, The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature. | en |
dc.language.iso | en | en |
dc.source | European Journal of Orthopaedic Surgery and Traumatology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112372293&doi=10.1007%2fs00590-021-03092-z&partnerID=40&md5=6620f6fd3dec5fc5ab4941480ce8c63a | |
dc.subject | calcium | en |
dc.subject | vitamin D | en |
dc.subject | zoledronic acid | en |
dc.subject | vitamin | en |
dc.subject | vitamin D | en |
dc.subject | zoledronic acid | en |
dc.subject | aged | en |
dc.subject | American Society of Anaesthesiologists score | en |
dc.subject | Article | en |
dc.subject | Barthel index | en |
dc.subject | Charlson Comorbidity Index | en |
dc.subject | clinical outcome | en |
dc.subject | clinical trial | en |
dc.subject | cohort analysis | en |
dc.subject | controlled study | en |
dc.subject | dementia | en |
dc.subject | drug effect | en |
dc.subject | drug megadose | en |
dc.subject | female | en |
dc.subject | femur pertrochanteric fracture | en |
dc.subject | follow up | en |
dc.subject | fracture treatment | en |
dc.subject | functional assessment | en |
dc.subject | hip fracture | en |
dc.subject | hip function | en |
dc.subject | hospitalization | en |
dc.subject | human | en |
dc.subject | joint function | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | mortality | en |
dc.subject | multivariate logistic regression analysis | en |
dc.subject | pain assessment | en |
dc.subject | postoperative complication | en |
dc.subject | postoperative period | en |
dc.subject | preoperative period | en |
dc.subject | prospective study | en |
dc.subject | univariate analysis | en |
dc.subject | very elderly | en |
dc.subject | hip fracture | en |
dc.subject | Hip Fractures | en |
dc.subject | Humans | en |
dc.subject | Prospective Studies | en |
dc.subject | Vitamin D | en |
dc.subject | Vitamins | en |
dc.subject | Zoledronic Acid | en |
dc.subject | Springer-Verlag Italia s.r.l. | en |
dc.title | The effect of zoledronic acid and high-dose vitamin D on function after hip fractures. A prospective cohort study | en |
dc.type | journalArticle | en |