dc.creator | Kountouras J., Boziki M., Polyzos S.A., Katsinelos P., Gavalas E., Zeglinas C., Tzivras D., Romiopoulos I., Giorgakis N., Anastasiadou K., Vardaka E., Kountouras C., Kazakos E., Xiromerisiou G., Dardiotis E., Deretzi G. | en |
dc.date.accessioned | 2023-01-31T08:45:27Z | |
dc.date.available | 2023-01-31T08:45:27Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1080/10715762.2016.1271122 | |
dc.identifier.issn | 10715762 | |
dc.identifier.uri | http://hdl.handle.net/11615/75310 | |
dc.description.abstract | Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Helicobacter pylori infection is also associated with variety of systemic extragastric diseases in which H. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed that Hp-related ROS may play a crucial role in the pathophysiology of Hp-related systemic diseases including Alzheimer’s disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden. Moreover, we postulated that H. pylori-related ROS might also be involved in the pathogenesis of extragastric common malignancies, thereby suggesting that H. pylori eradication might inhibit the development or delay the progression of aforementioned diseases. However, large-scale future studies are warranted to elucidate the proposed pathophysiological mechanisms, including H. pylori-related ROS, involved in H. pylori-associated systemic and malignant conditions. © 2017 Informa UK Limited, trading as Taylor & Francis Group. | en |
dc.language.iso | en | en |
dc.source | Free Radical Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009809574&doi=10.1080%2f10715762.2016.1271122&partnerID=40&md5=c479b34541795b99d2eafe97287ec82d | |
dc.subject | reactive oxygen metabolite | en |
dc.subject | reactive oxygen metabolite | en |
dc.subject | Alzheimer disease | en |
dc.subject | Article | en |
dc.subject | bacterial clearance | en |
dc.subject | Barrett esophagus | en |
dc.subject | colorectal cancer | en |
dc.subject | degenerative disease | en |
dc.subject | esophageal adenocarcinoma | en |
dc.subject | glaucoma | en |
dc.subject | Helicobacter pylori | en |
dc.subject | human | en |
dc.subject | malignant neoplasm | en |
dc.subject | multiple sclerosis | en |
dc.subject | nonhuman | en |
dc.subject | pathophysiology | en |
dc.subject | stomach disease | en |
dc.subject | systemic disease | en |
dc.subject | animal | en |
dc.subject | Helicobacter infection | en |
dc.subject | Helicobacter pylori | en |
dc.subject | host pathogen interaction | en |
dc.subject | immunology | en |
dc.subject | metabolism | en |
dc.subject | microbiology | en |
dc.subject | Animals | en |
dc.subject | Helicobacter Infections | en |
dc.subject | Helicobacter pylori | en |
dc.subject | Host-Pathogen Interactions | en |
dc.subject | Humans | en |
dc.subject | Neurodegenerative Diseases | en |
dc.subject | Reactive Oxygen Species | en |
dc.subject | Taylor and Francis Ltd | en |
dc.title | Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis | en |
dc.type | journalArticle | en |