dc.creator | Kotsiou O.S., Jagirdar R.M., Papazoglou E.D., Hatzoglou C., Gourgoulianis K.I., Zarogiannis S.G. | en |
dc.date.accessioned | 2023-01-31T08:44:49Z | |
dc.date.available | 2023-01-31T08:44:49Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1007/s10753-019-01070-6 | |
dc.identifier.issn | 03603997 | |
dc.identifier.uri | http://hdl.handle.net/11615/75217 | |
dc.description.abstract | Interleukin 33 (IL-33) is an alarmin with multiple roles in immunity and cell homeostasis, highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). Production of IL-33 and soluble ST2 (sST2), a decoy receptor for IL-33, has been implicated in several pulmonary diseases, but both have been scarcely investigated in pleural diseases. The aim of this study was to determine the levels of IL-33 and sST2 in transudative (TrPEs), malignant (MPEs), and parapneumonic (PPEs) pleural effusions (PEs) and investigate the effect of PE fluids from each group with low and high IL-33/sST2 levels on MeT-5A cell adhesion and migration. IL-33 and sST2 pleural fluid levels were similar among TrPEs, MPEs, and PPEs. However, a significant correlation was found between IL-33 and LDH and in sST2 levels with lymphocyte counts in TrPEs. Additionally, in MPEs the levels of IL-33 correlated with the levels of sST2 and with the red blood cell counts. Furthermore, incubation of MeT-5A cells with MPEs and PPEs bearing low or high levels of IL-33/sST2 yielded significant differential effects on MeT-5A cell adhesion and migration. In MPEs, high IL-33/sST2 levels led to increased adhesion and migration of MeT-5A cells, while in PPEs the effect was the opposite, while no effect in both cell phenotypes was determined for TrPEs. These results reveal a clinical context dependent effect of the IL-33/sST2 axis in PEs. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. | en |
dc.language.iso | en | en |
dc.source | Inflammation | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071237201&doi=10.1007%2fs10753-019-01070-6&partnerID=40&md5=9ce629387ed4bc66ee23bcbf2868cb6e | |
dc.subject | albumin | en |
dc.subject | interleukin 33 | en |
dc.subject | lactate dehydrogenase | en |
dc.subject | somatostatin receptor 2 | en |
dc.subject | IL1RL1 protein, human | en |
dc.subject | IL33 protein, human | en |
dc.subject | interleukin 1 receptor like 1 protein | en |
dc.subject | interleukin 33 | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | cell adhesion | en |
dc.subject | cell differentiation | en |
dc.subject | cell migration | en |
dc.subject | clinical article | en |
dc.subject | comparative study | en |
dc.subject | controlled study | en |
dc.subject | correlational study | en |
dc.subject | erythrocyte count | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | in vitro study | en |
dc.subject | leukocyte differential count | en |
dc.subject | lymphocyte count | en |
dc.subject | male | en |
dc.subject | mesothelium cell | en |
dc.subject | MeT-5A cell line | en |
dc.subject | phenotype | en |
dc.subject | pleura biopsy | en |
dc.subject | pleura effusion | en |
dc.subject | pleura fluid | en |
dc.subject | wound closure | en |
dc.subject | cell adhesion | en |
dc.subject | cell motion | en |
dc.subject | cytology | en |
dc.subject | epithelium | en |
dc.subject | epithelium cell | en |
dc.subject | metabolism | en |
dc.subject | pleura effusion | en |
dc.subject | Cell Adhesion | en |
dc.subject | Cell Movement | en |
dc.subject | Epithelial Cells | en |
dc.subject | Epithelium | en |
dc.subject | Humans | en |
dc.subject | Interleukin-1 Receptor-Like 1 Protein | en |
dc.subject | Interleukin-33 | en |
dc.subject | Pleural Effusion | en |
dc.subject | Springer New York LLC | en |
dc.title | Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration | en |
dc.type | journalArticle | en |