Association of Pathology Markers with Somatostatin Analogue Responsiveness in Acromegaly
dc.creator | Kontogeorgos G., Markussis V., Thodou E., Kyrodimou E., Choreftaki T., Nomikos P., Lampropoulos K.I., Tsagarakis S. | en |
dc.date.accessioned | 2023-01-31T08:44:01Z | |
dc.date.available | 2023-01-31T08:44:01Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1155/2022/8660470 | |
dc.identifier.issn | 16878337 | |
dc.identifier.uri | http://hdl.handle.net/11615/75077 | |
dc.description.abstract | Background. Somatotroph adenomas (SAs) exhibit a variable responsiveness to somatostatin analogue (SS-a) treatment, a process that is not well understood. We investigated established and novel histological markers as predictors of SS-a responsiveness. Methods. We retrospectively investigated pathology samples from 36 acromegalic patients that underwent transsphenoidal surgery. Clinical, hormonal, and imaging data were available in 24/36 patients, before and after SS-a treatment. Specimens were semiquantitatively analyzed with immunocytochemistry for Ki-67, KER, SSTR-2, SSTR-5, ZAC-1, E-cadherin, and AIP. Results. Collectively, 18 (50%) adenomas were each classified as densely/sparsely granulated somatotroph adenomas (DGSAs/SGSAs), respectively. Patients that received preoperative SS-a had lower expression of SSTR-2 compared to those that did not (2.0 (1.0, 3.0) vs. 3.0 (3.0, 3.0), p = 0.042). Compared with DGSAs, SGSAs had higher Ki-67 labeling index (LI) (1.0 (0.5, 1.0) vs. 2.0 (1.0, 3.5), p = 0.013), and a higher proportion of high MR T2 signal (1 (6%) vs. 6 (33%), p = 0.035), and tended to express less ZAC-1 (p = 0.061) and E-cadherin (p = 0.067). In linear regression corrected for baseline growth hormone (GH), ZAC-1 immunostaining was significantly associated with a decrease in GH levels after SS-a treatment (beta (95% confidence interval): -1.53 (-2.80, -0.26), p = 0.021). No markers were associated with changes in circulating insulin-like growth factor-I (IGF-I) after treatment with SS-a. Conclusion. The novel marker ZAC-1 was associated with GH response to medical treatment with SS-a. The SGSA cases were characterized by higher Ki-67 values and MR T2 signals indicative of an inferior response to SS-a. These findings improve our understanding of the mechanisms underlying SA response to medical treatment. © 2022 George Kontogeorgos et al. | en |
dc.language.iso | en | en |
dc.source | International Journal of Endocrinology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139792027&doi=10.1155%2f2022%2f8660470&partnerID=40&md5=2968826de0a6091900533e6c69db83c6 | |
dc.subject | aryl hydrocarbon receptor interacting protein | en |
dc.subject | biological marker | en |
dc.subject | corticotropin | en |
dc.subject | follitropin | en |
dc.subject | growth hormone | en |
dc.subject | Ki 67 antigen | en |
dc.subject | prolactin | en |
dc.subject | protein KER | en |
dc.subject | somatomedin C | en |
dc.subject | somatostatin derivative | en |
dc.subject | somatostatin receptor 2 | en |
dc.subject | somatostatin receptor 5 | en |
dc.subject | thyrotropin | en |
dc.subject | unclassified drug | en |
dc.subject | uvomorulin | en |
dc.subject | zinc finger protein 1 | en |
dc.subject | acromegaly | en |
dc.subject | adult | en |
dc.subject | age distribution | en |
dc.subject | Article | en |
dc.subject | clinical article | en |
dc.subject | clinical feature | en |
dc.subject | controlled study | en |
dc.subject | disease marker | en |
dc.subject | female | en |
dc.subject | growth hormone secreting adenoma | en |
dc.subject | histopathology | en |
dc.subject | hormone determination | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | image analysis | en |
dc.subject | immunocytochemistry | en |
dc.subject | immunohistochemistry | en |
dc.subject | male | en |
dc.subject | preoperative period | en |
dc.subject | protein expression | en |
dc.subject | retrospective study | en |
dc.subject | sex difference | en |
dc.subject | transsphenoidal surgery | en |
dc.subject | treatment outcome | en |
dc.subject | treatment response | en |
dc.subject | Hindawi Limited | en |
dc.title | Association of Pathology Markers with Somatostatin Analogue Responsiveness in Acromegaly | en |
dc.type | journalArticle | en |
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