Computational study of the effect of gradient magnetic field in navigation of spherical particles
Ημερομηνία
2017Γλώσσα
en
Λέξη-κλειδί
Επιτομή
The use of spherical magnetic nanoparticles that are coated with drugs and can be navigated in arteries to attack tumors is proposed as an alternative to chemotherapy. Navigation of particles is due to magnetic field gradients that may be produced in an MRI device. In the present work, a computational study for the evaluation of the magnitude of the gradient magnetic field for particles navigation in Y bifurcations is presented. For this purpose, the presented method solves for the fluid flow and includes all the important forces that act on the particles in their discrete motion. The method is based on an iteration algorithm that adjusts the gradient magnetic field to minimize the particles' deviation from a desired trajectory. Using the above mentioned method, the appropriate range of the gradient magnetic field for optimum navigation of nanoparticles's aggregation is found. © Published under licence by IOP Publishing Ltd.
Collections
Related items
Showing items related by title, author, creator and subject.
-
A numerical model for aggregations formation and magnetic driving of spherical particles based on OpenFOAM®
Karvelas E.G., Lampropoulos N.K., Sarris I.E. (2017)Background and objective This work presents a numerical model for the formation of particle aggregations under the influence of a permanent constant magnetic field and their driving process under a gradient magnetic field, ... -
On the magnetic aggregation of Fe3O4 nanoparticles
Karvelas E.G., Lampropoulos N.K., Benos L.T., Karakasidis T., Sarris I.E. (2021)Background and objective In-vivo MRI-guided drug delivery concept is a personalized technique towards cancer treatment. A major bottleneck of this method, is the weak magnetic response of nanoparticles. A crucial improvement ... -
Blood flow and diameter effect in the navigation process of magnetic nanocarriers inside the carotid artery
Karvelas E.G., Lampropoulos N.K., Karakasidis T.E., Sarris I.E. (2022)Background and objective: Serious side effects are occurred during the cancer therapy. Magnetic driving of nanoparticles is a novel method for the elimination of these effects by supplying with anticancer drug or increase ...