Εμφάνιση απλής εγγραφής

dc.creatorKaragiota A., Chachami G., Paraskeva E.en
dc.date.accessioned2023-01-31T08:30:46Z
dc.date.available2023-01-31T08:30:46Z
dc.date.issued2022
dc.identifier10.3390/cancers14010228
dc.identifier.issn20726694
dc.identifier.urihttp://hdl.handle.net/11615/74351
dc.description.abstractAltered lipid metabolism is an emerging hallmark of aggressive tumors, as rapidly proliferating cancer cells reprogram fatty acid (FA) uptake, synthesis, storage, and usage to meet their increased energy demands. Central to these adaptive changes, is the conversion of excess FA to neutral triacylglycerides (TAG) and their storage in lipid droplets (LDs). Acylglycerolphosphate acyltransferases (AGPATs), also known as lysophosphatidic acid acyltransferases (LPAATs), are a family of five enzymes that catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), the second step of the TAG biosynthesis pathway. PA, apart from its role as an intermediate in TAG synthesis, is also a precursor of glycerophospholipids and a cell signaling molecule. Although the different AGPAT isoforms catalyze the same reaction, they appear to have unique non-overlapping roles possibly determined by their distinct tissue expression and substrate specificity. This is best exemplified by the role of AGPAT2 in the development of type 1 congenital generalized lipodystrophy (CGL) and is also manifested by recent studies highlighting the involvement of AGPATs in the physiology and pathology of various tissues and organs. Importantly, AGPAT isoform expression has been shown to enhance proliferation and chemoresistance of cancer cells and correlates with increased risk of tumor development or aggressive phenotypes of several types of tumors. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.sourceCancersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85122090934&doi=10.3390%2fcancers14010228&partnerID=40&md5=ab1ace08b3129464cace4fb771c59a77
dc.subjectacylglycerolphosphate acyltransferase 1en
dc.subjectacylglycerolphosphate acyltransferase 2en
dc.subjectacylglycerolphosphate acyltransferase 3en
dc.subjectacylglycerolphosphate acyltransferase 4en
dc.subjectacylglycerolphosphate acyltransferase 5en
dc.subjectacyltransferaseen
dc.subjectunclassified drugen
dc.subjectadipocyteen
dc.subjectcancer classificationen
dc.subjectcancer prognosisen
dc.subjectcell differentiationen
dc.subjectcell proliferationen
dc.subjectcomplex formationen
dc.subjectcongenital generalized lipodystrophyen
dc.subjectendoplasmic reticulumen
dc.subjectenzyme mechanismen
dc.subjectenzyme specificityen
dc.subjectferroptosisen
dc.subjectGolgi complexen
dc.subjecthealth statusen
dc.subjecthumanen
dc.subjectlipid metabolismen
dc.subjectlipid peroxidationen
dc.subjectlipid transporten
dc.subjectmalignant neoplasmen
dc.subjectmetastasisen
dc.subjectmitochondrionen
dc.subjectnonhumanen
dc.subjectnuclear reprogrammingen
dc.subjectphenotypeen
dc.subjectprotein expressionen
dc.subjectReviewen
dc.subjectsequence homologyen
dc.subjectsignal transductionen
dc.subjectMDPIen
dc.titleLipid Metabolism in Cancer: The Role of Acylglycerolphosphate Acyltransferases (AGPATs)en
dc.typeotheren


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής