dc.creator | Ismaeel A., Laudato J.A., Fletcher E., Papoutsi E., Tice A., Hwa L.S., Miserlis D., Jamurtas A.Z., Steiner J., Koutakis P. | en |
dc.date.accessioned | 2023-01-31T08:28:42Z | |
dc.date.available | 2023-01-31T08:28:42Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.3390/nu14051016 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | http://hdl.handle.net/11615/74067 | |
dc.description.abstract | Previous studies have shown that chronic heavy alcohol consumption and consumption of a high-fat (HF) diet can independently contribute to skeletal muscle oxidative stress and mitochondrial dysfunction, yet the concurrent effect of these risk factors remains unclear. We aimed to assess the effect of alcohol and different dietary compositions on mitochondrial activity and oxidative stress markers. Male and female mice were randomized to an alcohol (EtOH)-free HF diet, a HF + EtOH diet, or a low-Fat (LF) + EtOH diet for 6 weeks. At the end of the study, electron transport chain complex activity and expression as well as antioxidant activity and expression, were measured in skeletal muscles. Complex I and III activity were diminished in muscles of mice fed a HF + EtOH diet relative to the EtOH-free HF diet. Lipid peroxidation was elevated, and antioxidant activity was diminished, in muscles of mice fed a HF + EtOH diet as well. Consumption of a HF diet may exacerbate the negative effects of alcohol on skeletal muscle mitochondrial health and oxidative stress. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Nutrients | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125958261&doi=10.3390%2fnu14051016&partnerID=40&md5=eb71e0f929a0f1fc264a40d27e680c7d | |
dc.subject | alcohol | en |
dc.subject | aldehyde dehydrogenase isoenzyme 2 | en |
dc.subject | glutathione peroxidase | en |
dc.subject | malonaldehyde | en |
dc.subject | messenger RNA | en |
dc.subject | multienzyme complex | en |
dc.subject | myoglobin | en |
dc.subject | reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) | en |
dc.subject | superoxide dismutase | en |
dc.subject | ubiquinol cytochrome c reductase | en |
dc.subject | alcohol | en |
dc.subject | adult | en |
dc.subject | alcohol consumption | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | antioxidant activity | en |
dc.subject | Article | en |
dc.subject | body weight | en |
dc.subject | controlled study | en |
dc.subject | diet composition | en |
dc.subject | disease exacerbation | en |
dc.subject | disorders of mitochondrial functions | en |
dc.subject | enzyme activity | en |
dc.subject | female | en |
dc.subject | gastrocnemius muscle | en |
dc.subject | gene expression profiling | en |
dc.subject | lipid diet | en |
dc.subject | lipid peroxidation | en |
dc.subject | low fat diet | en |
dc.subject | male | en |
dc.subject | mouse | en |
dc.subject | mRNA expression level | en |
dc.subject | muscle mitochondrion | en |
dc.subject | muscle weight | en |
dc.subject | nonhuman | en |
dc.subject | oxidative stress | en |
dc.subject | protein expression | en |
dc.subject | skeletal muscle | en |
dc.subject | adverse event | en |
dc.subject | animal | en |
dc.subject | metabolism | en |
dc.subject | mitochondrion | en |
dc.subject | randomized controlled trial | en |
dc.subject | Animals | en |
dc.subject | Diet, High-Fat | en |
dc.subject | Ethanol | en |
dc.subject | Female | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mitochondria | en |
dc.subject | Muscle, Skeletal | en |
dc.subject | Oxidative Stress | en |
dc.subject | MDPI | en |
dc.title | High-Fat Diet Augments the Effect of Alcohol on Skeletal Muscle Mitochondrial Dysfunction in Mice | en |
dc.type | journalArticle | en |